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EC number: 911-418-6 | CAS number: 55965-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Other distribution data
Administrative data
- Endpoint:
- other distribution data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. Environmental Protection Agency, 40 CFR § 158, Subdivision N, Chemistry, Environmental Fate 163-1
- Deviations:
- no
- GLP compliance:
- no
- Type of study:
- soil leaching
- Media:
- water - soil
Test material
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Rohm and Haas, Batch No. 555.0104h2
RADIOLABELLING INFORMATION (if applicable)
- Radiochemical purity: 96.58%
- Specific activity: 38.4 mCi/g
- Locations of the label: 14C label was at the 4 and 5 position
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Not reported
- Stability under test conditions: The half life of CMIT was determined previously in a sandy loam soil to be 5.5 hours
- Solubility and stability of the test substance in the solvent/vehicle: Water solubility (deionized water) > 1000 ppm
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Approximately 370 μCi (~9.6 mg) of 14C CMIT was dissolved in 3.5 mL of ethanol
- Final dilution of a dissolved solid, stock liquid or gel: The solution was radioassayed and found to contain 233, 180 dpm per microliter (2.74 μg/μL)
FORM AS APPLIED IN THE TEST (if different from that of starting material)
Liquid
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The study provided satisfactorily describes the mobility for CMIT and its soil metabolites per U.S. Environmental Protection Agency, 40 CFR § 158, Subdivision N, Chemistry, Environmental Fate 163-1. Parent and its metabolites had intermediate mobility as over 50% of the applied activity was not mobile. Since the adsorption coefficient indicates that parent is mobile, the lack of parent’s detection in the leachate is probably the result of continued degradation while passing through the column. It is highly likely that with continuing time parent degrades to metabolites which subsequently form a tight association with the post extraction solids becoming bound and of very limited mobility.
- Executive summary:
The test guideline followed were U.S. Environmental Protection Agency, 40 CFR § 158, Subdivision N, Chemistry, Environmental Fate 163-1. There were four minor GLP deviations; 1) soil was not analyzed under GLP protocols but employed proper scientific practices, 2) some of the chromatographic standards were not analyzed by GLP protocols, 3) some automated data collection was dated by the computer rather than by personnel, and 4) some aliquot values taken for LSC were first recorded on LSC vial caps and then transcribed to LSC printouts. None of these deviations had a detrimental impact on the study.
Initially, 100 g of Pasquotant sandy loam was added to biometer flasks and dosed with 1 ppm14C CMIT. Volatiles were trapped using KOH in the side arm. After 5 hours (~ one half-life) the soil from 6 of the biometer flasks were combined, mixed into a single sample, and radioassayed.
Leaching columns were prepared by placing air dried and sieved sand, sandy loam, silt loam or clay loam soil into duplicate glass columns prepared from 6 cm tall glass rings. The final packed column length was 30 cm. The soils were wetted with 0.01M CaCl2(from the bottom up) and after removing the excess of water removed. To the top of each 30 cm soil column, 50 g of the aged14C CMIT treated sandy loam soil was added. The equivalent of 50 cm of rain (on a cross sectional area bases; 529 mL of 0.01M CaCl2) was added to each column, the leachate collected, and radioassayed. At the conclusion, the 6 cm rings were separated , the soil removed, and radioassayed.Approximately 55%-64% of the applied activity was not mobile and remained in the treated soil segment. In the sandy loam, clay loam and silt loam soils, the 6 cm segment immediately below the treated soil contained about 10-12% of the applied activity. Lower segments had successively decreasing percentages of radioactivity. In the sand, the decrease was not pronounced as the segment immediately below the treated soil had 1.96% of the applied and the bottom segment, 1.49%. The amount of applied activity in the leachate ranged from 15.17% (Lansdale silt loam) to 35.55% (Lakeland sand). In the treated segment of soil placed on top of the column, parent comprised about 25% of the applied activity, metabolites about 10%, volatiles about 5% and bound residues about 50%. In the 6 cm segment immediately below the treated segment, over 93% of the activity was in the post extraction solids and is considered to be bound residue.
No parent was detectable in the leachate. The metabolites were polar and primarily acidic in nature. The major ones cochromatographed with standards of malonamic acid, malonic acid, N-methyl malonamic acid, and N-methyl oxamic acid.
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