Registration Dossier
Registration Dossier
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EC number: 459-990-1 | CAS number: 52411-34-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 423
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 459-990-1
- EC Name:
- -
- Cas Number:
- 52411-34-4
- Molecular formula:
- Hill formula: C14H16N2O2 CAS formula: C14H16N2O2
- IUPAC Name:
- 1,2-Bis(2-aminophenoxy)ethane
Constituent 1
Test animals
- Species:
- other: rat, Sprague-Dawley Hsd:(SD)
Administration / exposure
- Vehicle:
- other: Suspension in 20 % Tylose
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Female: 2000 mg/kg bw; Number of animals: 6; Number of deaths: 0
- Clinical signs:
- Signs of toxicity related to dose levels:
Im Verlauf der Studie ist kein Tier gestorben. Ab 30 Min.
bis 1 h p.a. traten folgende unspezifischen Symptome auf:
Hockstellung, gestelzter und unkoordinierter Gang,
unregelmäßige Atmung, eingezogene Flanken, Hyperaktivität,
verengte Lidspalten, gesträubtes Fell und gelbliche
Verfärbung der Einstreu. Ab dem 7. Tag p.a. waren die
Effekte reversibel.
2 Tiere zeigten am Ende der Studie einen leichten
Körpergewichtsverlust. Bei den anderen Tieren war die
Körpergewichtsentwicklung nicht beeinflusst.
"ENGLISH"
No animal died in the course of the study. The following
unspecific symptoms occurred from 30 min to 1 h p.a.
Crouched posture, high-legged and uncoordinated gait,
irregular breathing, contracted flanks, hyperactivity,
narrowed eyelids, piloerection and yellow discoloration of
the bedding. The effects were reversible from the 7th day.
2 animals exhibited a slight loss in body weight at the end
of the study. There was no influence on the body-weight
gain of the other animals. - Gross pathology:
- Effects on organs:
Bei der Sektion der Tiere am Ende der Studie wurden keine
makroskopisch sichtbaren Effekte festgestellt.
"ENGLISH"
No macroscopically visible effects were determined during
the necropsy of the animals at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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