Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-288-1 | CAS number: 611-99-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 48 hours
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- Test solution preparation was slightly different than prescribed. supported by the analytical confirmation which showed very good recoveries meaning that most/all the material was in solution
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Lot/Batch Number: 20111104
Purity/Composition: >99.5% CAS # 611-99-4
Chemex reference: ECO 170601 - Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- Test concentrations: 0 (control), 10, 18, 32, 58, and 100 mg/l
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Source: From cultures maintained at Chemex Environmental International Ltd since July 2014 and originally sourced from a clone of genotype 5.
Date of gravid isolation: 13 November 2017
Age of Daphnia at start of test: ≤ 24 hours.
Culture conditions: Cultured under static conditions
Temperature: 20 ± 2°C
Dissolved oxygen: >60% (or 3mg/l) ASV
Photoperiod: 16 hours light and 8 hours dark
Feeding regime: Each working day, a suspension of Chlorella vulgaris. The Daphnia in the test were not fed. - Test type:
- static
- Water media type:
- other: Elendt M4 reconstituted Daphnia water - cultured water, controlled conditions
- Total exposure duration:
- 48 h
- Test temperature:
- Temperature range within incubator throughout test: 19.4 – 20.0 °C
(Required: 20±2°C maintained to ±1°C) - pH:
- pH range in control and test concentrations throughout test: 6.62 – 7.88
- Dissolved oxygen:
- Initial Dissolved Oxygen at 0 Hours: 6.84mg/l
DO range in control and test concentrations throughoutn test: 6.28 – 7.80mg/l
(Required: ≥3mg/l) - Details on test conditions:
- The test was carried out according to the procedures given below, and SOP E201 based on the OECD 202 guideline Daphnia sp. Acute Immobilisation Test.
Chemex SOP reference: E201 “Daphnia magna 24 & 48 hr EC50 acute immobilisation test”
Preliminary test method: A preliminary (range-finding) test was conducted at concentrations of 0 (control), 0.1, 1, 10 and 100mg/l.
The duration of the preliminary test was 48 ± 1 hours.
There was a single replicate at each concentration.
Preliminary test results: Data from the preliminary test identified the 48-hour EC50 as being between 10-100mg/l. - Reference substance (positive control):
- yes
- Remarks:
- A separate GLP study (ENV 11395) was conducted to monitor the sensitivity of the test animals and test procedures. The reference study gave a 24 hour EC50 of 1.4mg/l of potassium dichromate which was within the acceptable range 0.6 mg/l to 2.1 mg/l
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 41.84 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 34.09 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 24-hour EC50 and 48-hour EC50 of 4,4 DIHYDROXYBENZOPHENONE to Daphnia magna were 41.8366mg/l and 34.092mg/l respectively.
The 0 to 24-hour NOEC and LOEC were 18mg/l and 32 mg/l respectively
The 0 to 48-hour NOEC and LOEC were 18mg/l and 32 mg/l respectively
The lowest test concentration which immobilised all twenty Daphnia after 48-hours was 58mg/l.
The highest concentration where no immobilisation occurred was 18mg/l.
Reference
Description of key information
The 24-hour EC50 and 48-hour EC50 of 4,4 DIHYDROXYBENZOPHENONE to Daphnia magna were 41.8366mg/l and 34.092mg/l respectively.
The 0 to 24-hour NOEC and LOEC were 18mg/l and 32 mg/l respectively
The 0 to 48-hour NOEC and LOEC were 18mg/l and 32 mg/l respectively
The lowest test concentration which immobilised all twenty Daphnia after 48-hours was 58mg/l.
The highest concentration where no immobilisation occurred was 18mg/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 34.092 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.