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EC number: 947-398-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Glycerides, C16-18 mono-, di- and tri-, hydrogenated, citrates is not considered to be sensitizing to the skin.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No information on skin sensitisation of Glycerides, C16-18 mono-, di- and tri-, hydrogenated, citrates was identified. However, two studies from structural analogues are available.
In a Guinea Pig Maximisation Test according to OECD TG 406 under GLP conditions, the skin sensitizing potential of Glycerides, C16-18 mono-, di- and tri-, hydrogenated, citrates, sodium salts (CAS 91744 -39 -7) was assessed, using 10 test and 5 control animals (Goldschmidt AG, 1996). Based on a range finding tests, the animals were exposed (epicutaneous, occlusive) to 50% of the test substance prepared in vaseline after a series of intradermal injections (5% test substance). The animals were subjected two weeks later to a challenge exposure with the test substance and the control substance for the control group. Responses to the challenge procedure were evaluated 24 and 48 h after the end of the exposure period. No allergic skin reactions occurred in test animals 24 and 48 h after the end of the challenge procedure. The sensitisation rate was 0 %. No findings were observed in control animals. Based on these results, it was concluded that the test substance does not have a sensitising effect on the skin of the guinea pig in the Buehler test under the test conditions chosen.
The sensitizing potential of the test substance (CAS 91744-23-9) was investigated in a study according to OECD Guideline No. 406 "Skin Sensitization (maximization test)”. The following animal numbers were used in the study: 20 (main experiment), 3 (pilot study), 3 (determination of challenge concentration), control animals: 10. The substance concentrations for induction and challenge were 2, 25, 50, and 100 % in corn oil MEH 56. 2 -Mercaptobenzothiazole served as positive control. Experimental animals were epidermally exposed to undiluted test substance on days 0, 7, and 14 (occlusive dermal applications for 6 hours, scoring at 30 hours after start of application). Control animals were exposed to vehicle only. On day 28 animals were challenged with undiluted test substance (occlusive dermal application for 6 hours). Evaluations were made after 24 and 48 h.
Under the conditions of the test no sensitizing effects of the test substance could be observed. In addition, no clinical effects were observed. Body weight increase of the test animals was comparable to the control. Based on these results, it was concluded that the test substance does not have a sensitising effect on the skin of the guinea pig in the Guinea Pig Maximisation Test under the test conditions chosen.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
No information on respiratory sensitisation of Glycerides, C16-18 mono-, di- and tri-, hydrogenated, citrates was identified.
Justification for classification or non-classification
Based on the available information, classification for skin sensitisation is not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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