Triethyl O-acetylcitrate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

presumably 1974

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Only results given. Publication has lack of methodical details

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Reference 2

Reference Type:

publication

Title:

Final Report on the Safety Assessment of Acetyl Triethyl Citrate, Acetyl Tributyl Citrate, Acetyl Trihexyl Citrate, and Acetyl Trioctyl Citrate

Author:

Cosmetic Ingredient Review

Year:

2002

Bibliographic source:

International Journal of Toxicology, 21(Suppl. 2):1–17

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

1.) 3 male albino rabbits were used. The abdomen were closely clipped and 1 mL/kg bw was placed on the intact skin daily for 4 days. The animals were observed daily and for a period of 36 h after the last application.

2.) 3 male albino rabbits were used. 1 mL/kg was placed on the closely clipped abdomen for a total of 18 applications (6 d per week). Animals were observed daily and for a period of two weeks following the last application.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Triethyl O-acetylcitrate

EC Number:

201-066-5

EC Name:

Triethyl O-acetylcitrate

Cas Number:

77-89-4

Molecular formula:

C14H22O8

IUPAC Name:

triethyl 2-acetoxypropane-1,2,3-tricarboxylate

Test animals

Species:

rabbit

Strain:

other: Albino

Details on test animals or test system and environmental conditions:

no further data

Test system

Type of coverage:

not specified

Preparation of test site:

other: intact / abraded

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

1 mL/kg bw (ca. 1000 mg/kg)

Duration of treatment / exposure:

4 - 18 applications

Observation period:

36 h to 2 weeks after last application

Number of animals:

2-3

Details on study design:

see above

Results and discussion

In vivo

Results

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

No irritant effects noted

Any other information on results incl. tables

Individual scores were not given. Examination time points: 36 h to 2 weeks after last application.

The skin irritation potential of Acetyl Triethyl Citrate was evaluated using three male albino rabbits. The test substance (1 cc/kg body weight) was inuncted onto intact abdominal skin that had been clipped free of hair. This procedure was repeated daily for 4 days. The animals were observed daily for up to 36 hours after the last application. Acetyl Triethyl Citrate did not induce skin irritation in any of the three rabbits tested .

In another study, Acetyl Triethyl Citrate (1 cc/kg body weight) was inuncted onto intact abdominal skin of each of three male albino rabbits for a total of 18 applications (6 days/week). The animals were then observed over a period of 2 weeks. Body weights were normal throughout the study. Skin irritation was not observed in any of the animals .

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

ATEC was not skin irritating. Classification criteria are not meet.

Executive summary:

In all of the 2 trials there was no indication for skin irritation.