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Diss Factsheets
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EC number: 221-029-7 | CAS number: 2978-58-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1969-05-06
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- internal method
- Principles of method if other than guideline:
- The potential of acute eye irritation was assessed by a single instillation of 0.1 mL test substance into the conjunctival sac of the left eye of nine rabbits. Three eyes were irrigated with tap water two seconds after application, three after four seconds and three eyes were not irrigated, but held closed for one second. During the test, untreated right eyes served as controls. Body weights were recorded both initially and terminally. Corneal demage was proven on day 7, 10 or 14 with 2.0% sodium fluorescein stain. Observations on gross pathology and systematic toxicology were made 24, 48, and 72 hours and 4, 7, 10, and 14 days following application. The acute eye irritation was graded according to Draize, J. H., from the Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics, Assn. of Food and Drug Offcials of the U. S., Austin, Texas, 1959.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,1-dimethylprop-3-ynylamine
- EC Number:
- 221-029-7
- EC Name:
- 1,1-dimethylprop-3-ynylamine
- Cas Number:
- 2978-58-7
- Molecular formula:
- C5H9N
- IUPAC Name:
- 2-methylbut-3-yn-2-amine
Constituent 1
- Specific details on test material used for the study:
- - clear, colorless liquid with a pungent odor
- material assumed to contain 100% active ingredient
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- - Body weight range at initiation: 2.0 to 3.1 kg.
- Diet: Purina Rabbit Chow and water available ad libitum
- eyes judged free of irritation and corneal damage (confirmed by sodium fluorescein examination) prior to initiation of study
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- other: untreated right eyes served as controls.
- Amount / concentration applied:
- - 0.1 mL
- Duration of treatment / exposure:
- - two and four seconds
- Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 9 individuals
- Details on study design:
- - Application of test substance: single application into the conjunctival sac of the left eye
- Posttreatment: 3 eyes irrigated with 20 mL tap water two seconds after application; 3 eyes not irrigated but held closed for 2 seconds
Results and discussion
In vivo
Results
- Irritation parameter:
- other: histopathological observations
- Remarks on result:
- other: See "Any other information on results incl. tables"
Any other information on results incl. tables
1. Principal Toxic Effects
On day 4, one animal with the eye irrigated after two seconds died. Several animals blinked and preened themselves immediately after application of the test item. Four animals showed moderate weight loss.
2. Gross Pathology
The following gross signs were observed: Blanched conjunctivae, marked conjunctival erythema in one irrigated eye, slight to marked chemosis and discharge, slight to moderate iritis, and slight to marked corneal opacity was noted from day through day 14. On Day 7, Day 10, and Day 14 corneal vascularization was noted in two eyes irrigated after two seconds. Due to extreme irritation and destruction of the eye, four irrigated eyes and the three nonirrigated eyes could not be completely graded by Day 10 or Day 14.
3. Terminal Fluorescein Examination
Corneal damage was shown on day 14 in two eyes irrigated after two seconds, in two eyes irrigated after four seconds and in the three nonirrigated eyes. Staining was not possible in the remaining two irrigated eyes because the animal died or the eye was destructed completely.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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