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Description of key information

Data available for the structurally similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical 2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6).The studies are as mentioned below:

1.In a acute oral toxicity study,rats were treated with test chemical in the concentration of 5000 mg/kg bw orally. No mortality observed in treated rats at 5000 mg/kg bw. Therefore,LD50 was considered to be > 5000 mg/kg bw,when rats were treated with test chemical orally.

2.Acute oral toxicity study was done in rats using test material Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate] (5160-02-1).No mortality was observed at dose 10000 mg/kg bw in treated rats.Hence,LD50 value was considered to be >10000 mg/kg bw,when rats were treated with Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate] (5160-02-1)orally.

3.Acute oral toxicity study was performed in rats using test chemical.No mortality was observed at dose10000 mg/kg bw.In clinical sign observations, changes on urine composition,behavioral somnolence (general depressed activity) and dermatitis were observed.Hence,LD50 value was considered to be >10000 mg/kg bw,when rats were treated with test chemical orally.

Thus, based on the above summarised studies,2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6) and it’s structurally similar read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation,2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6)cannot be classified for acute oral toxicity.Hence, based on the data available for the structurally similar read across, test chemical 2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6)is not likely to be toxic at the dose of 10000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Related information:
Composition 1
Reason / purpose:
read-across source
Related information:
Composition 1
Reason / purpose:
read-across source
Related information:
Composition 1
Reference:
Composition 0
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two acute oral toxicity studies as-
1.,2. and 3. Acute Oral toxicity test was carried out to study the effects of the test chemicals on rodents
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
no
Test material information:
Composition 1
Specific details on test material used for the study:
- Name of test material : 2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107
- IUPAC name : 2-[(E)-2-(4-{4-[(E)-2-(2-hydroxy-5-nonylphenyl)diazen-1-yl]-3-methylphenyl}-2-methylphenyl)diazen-1-yl]-4-nonylphenol
- Molecular formula : C44H58N4O2
- Molecular weight : 674.9682 g/mol
- Smiles notation : CCCCCCCCCC1=CC(=NNC2=C(C=C(C=C2)C3=CC(=C(C=C3)NN=C4C=C(C=CC4=O)CCCCCCCCC)C)C)C(=O)C=C1
- InChl : 1S/C44H58N4O2/c1-5-7-9-11-13-15-17-19-35-21-27-43(49)41(31-35)47-45-39-25-23-37(29-33(39)3)38-24-26-40(34(4)30-38)46-48-42-32-36 (22-28-44(42)50)20-18-16-14-12-10-8-6-2/h21-32,49-50H,5-20H2,1-4H3/b47-45+,48-46+
- Substance type: Organic
- Physical state: Solid (Off white to slight yellow)
Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
1.No data available
Route of administration:
other: 1.oral: unspecified
Vehicle:
other: 1.not specified
Details on oral exposure:
not specified
Doses:
1.5000 mg/kg bw
2.10000 mg/kg bw
3.10000 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
1.not specified
2.not specified
3.Details on study design:
-Other examinations performed: clinical signs
Statistics:
not specified
Preliminary study:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 - < 10 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no mortality was observed
Mortality:
1.No mortality was observed at dose 5000 mg/kg bw in treated rats
2.No mortality was observed at dose 10000 mg/kg bw in treated rats
3.No mortality was observed at dose 10000 mg/kg bw in treated rats
Clinical signs:
1.No data available
2.No data available
3.In clinical sign observations,changes on urine composition,behavioral somnolence (general depressed activity) and dermatitis were observed.
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available
Interpretation of results:
other: not classified
Conclusions:
The test chemical 2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6) is not likely to be toxic in the dose of 10000 mg/kg bw.
Executive summary:

Data available for the structurally similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical 2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6).The studies are as mentioned below:

1.In a acute oral toxicity study,rats were treated with test chemical in the concentration of 5000 mg/kg bw orally. No mortality observed in treated rats at 5000 mg/kg bw. Therefore,LD50 was considered to be > 5000 mg/kg bw,when rats were treated with test chemical orally.

2.Acute oral toxicity study was done in rats using test material Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate] (5160-02-1).No mortality was observed at dose 10000 mg/kg bw in treated rats.Hence,LD50 value was considered to be >10000 mg/kg bw,when rats were treated with Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate] (5160-02-1)orally.

3.Acute oral toxicity study was performed in rats using test chemical.No mortality was observed at dose10000 mg/kg bw.In clinical sign observations, changes on urine composition,behavioral somnolence (general depressed activity) and dermatitis were observed.Hence,LD50 value was considered to be >10000 mg/kg bw,when rats were treated with test chemical orally.

Thus, based on the above summarised studies,2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6) and it’s structurally similar read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation,2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6)cannot be classified for acute oral toxicity.Hence, based on the data available for the structurally similar read across, test chemical 2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6)is not likely to be toxic at the dose of 10000 mg/kg bw.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
10 000 mg/kg bw
Quality of whole database:
Data is Klimisch 2 and from secondary source

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Data available for the structurally similar read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical 2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6).The studies are as mentioned below:

1.In a acute oral toxicity study,rats were treated with test chemical in the concentration of 5000 mg/kg bw orally. No mortality observed in treated rats at 5000 mg/kg bw. Therefore,LD50 was considered to be > 5000 mg/kg bw,when rats were treated with test chemical orally.

2.Acute oral toxicity study was done in rats using test material Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate] (5160-02-1).No mortality was observed at dose 10000 mg/kg bw in treated rats.Hence,LD50 value was considered to be >10000 mg/kg bw,when rats were treated with Barium bis[2-chloro-5-[(2-hydroxy-1-naphthyl)azo]toluene-4-sulphonate] (5160-02-1)orally.

3.Acute oral toxicity study was performed in rats using test chemical.No mortality was observed at dose10000 mg/kg bw.In clinical sign observations, changes on urine composition,behavioral somnolence (general depressed activity) and dermatitis were observed.Hence,LD50 value was considered to be >10000 mg/kg bw,when rats were treated with test chemical orally.

Thus, based on the above summarised studies,2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6) and it’s structurally similar read across substance, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation,2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6)cannot be classified for acute oral toxicity.Hence, based on the data available for the structurally similar read across, test chemical 2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6)is not likely to be toxic at the dose of 10000 mg/kg bw.

Justification for classification or non-classification

Based on the above experimental studies on 2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6) and it’sstructurally similar read across substances, it can be concluded that LD50 value is greater than 2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation,2,2'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-nonylphenol] / C.I. Solvent Yellow 107 (67990-27-6) cannot be classified for acute oral toxicity.