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EC number: 201-851-2 | CAS number: 88-68-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, guideline study, available as unpublished report, no restrictions, fully adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Anthranilamide
- EC Number:
- 201-851-2
- EC Name:
- Anthranilamide
- Cas Number:
- 88-68-6
- Molecular formula:
- C7H8N2O
- IUPAC Name:
- 2-aminobenzamide
- Details on test material:
- - Name of the test substance used in the study report: Anthranilamid
- Physical state / Appearance: solid ( powder)/brown
- Storage: at room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr . K . Thomae GmbH, D-7950 Biberach, FRG
- Age at study initiation: approx. 8 - 9 weeks
- Weight at study initiation: male animals 268 ± 2.5 g, female animals 189 ± 7.1 g.
- Housing: groups of five in cages type D III of Becker, without bedding.
- Diet: KLIBA rat/mouse laboratory diet 24-343-4 10 mm pellets (Klingentalmühle AG, CH-4303 Kaiseraugst, Switzerland), ad libitum.
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Air changes (per hr): Fully aircondidtioned
- Photoperiod (hrs dark / hrs light): 12 /12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Details on inhalation exposure:
- - Generation of the inhalation atmosphere: A dust aerosol was generated by means of a dosing-wheel dust generator (Gericke/BASF). The test substance was mixed with 1 wt% of Aerosil in order to achieve a more uniform dust concentration in air. The concentration was adjusted by varying rotation of the metering disc.
- The following air flow (supply air) was set: compressed air : 1500 L/h. The exposure system was placed in an air-conditioned laboratory. Temperatures in the exposure system were 19 - 25°C. By means of an exhaust air system the pressure ratios in the inhalation system were adjusted in such a way that the amount of exhaust air was about 10% lower (excess pressure). This ensured that the mixture of test substance and air was not diluted with laboratory air in the breathing zones of the animals.
Analytical method used: Gravimetric determination of the inhalation atmosphere concentration. The preweighed filter was placed into the filtration
equipment. By means of a vacuum compressed air pump a volume of the dust aerosol was drawn through the filter. The dust concentration in mg/L was calculated from the difference between the preweight of the filter and the weight of the filter after sampling, with reference to the sample volume of the inhalation atmosphere. The concentration was corrected for the amount of the additive (1 sample about hourly). - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5.4 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- other: historical control for body weight
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Body weight was checked before the beginning of the test, after 7 days and at the end of the observation period. Clinical findings were recorded several times during exposure and at least once on each workday in the observation period. A check for dead animals was made daily.
- Necropsy of survivors performed: yes, at the end of the 14-day observation period the animals were sacrificed with CO2 and were subjected to gross-pathological examination. - Statistics:
- On the basis of the binomial test (Wittig, H. : Mathematische Statistik 1974, pp. 32 - 35).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.4 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- None
- Clinical signs:
- other: - During exposure: accelerated respiration - After exposure and during observation period: accelerated respiration (10/10), reddish nasal (2/10) and eye discharges (1/10) (blood test positive), and fur discoloured with the test substance (10/10) was obser
- Body weight:
- - Mean body weight for male animals: 268 g at study start, 330 g after 14 days
- Mean body weight for female animals: 189 g at study start, 206 g after 14 days - Gross pathology:
- No pathological findings noted.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
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