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EC number: 231-335-2 | CAS number: 7493-74-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Non-GLP study performed acccording to guidelines of the USA Interagency Regulatory Liaison Group (IRLG) Testing Standards and Guidelines Work Group (January 1981). No information on purity was given; occlusive application
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- The skin was abraded prior to treatment; occlusive application; No information on purity was given.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Allyl phenoxyacetate
- EC Number:
- 231-335-2
- EC Name:
- Allyl phenoxyacetate
- Cas Number:
- 7493-74-5
- Molecular formula:
- C11H12O3
- IUPAC Name:
- allyl phenoxyacetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7-11 weeks
- Weight at study initiation: 225-240 g (males), 205-220 g (females)
- Fasting period before study: overnight prior to dosing
- Housing: individually in solid-bottom polypropylene boxes, softwood sawdust was used as bedding material
- Diet: R 4 Alleindiät für Ratten (Ssniff Versuchstier-GmbH, Soest, Germany), ad libitum
- Water: ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-23
- Humidity (%): 40-70
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back and flanks
- % coverage: 10%
- Type of wrap if used: The treated skin was covered with a porous gauze dressing and occluded with a strip of impermeable adhesive plaster wound around the trunk.
The application site was abraded using a sterile clipper head immediately prior to treatment.
REMOVAL OF TEST SUBSTANCE
- Washing: The skin and surrounding areas were wiped with a moist disposable towel to remove any residual test substance.
- Time after start of exposure: 24 h
TEST MATERIAL
- Amounts applied: 1.7 mL/kg bw
- Constant concentration used: yes - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed 15 and 30 min and 1, 2 and 4 h after administration and subsequently once daily for 14 days. Individual body weights were determined on day before treatment (Day -1), on the day of treatment (Day 0) and 7 and 14 days after treatment.
- Necropsy of survivors performed: yes
- Other examinations performed: histopathological examination of the kidney, liver and (treated) skin tissue of 3 males and 3 females
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred during the study period of the main study.
- Clinical signs:
- other: Clinical changes like lacrimation, half-closed eyes, soft faeces and exophthalmia were observed on the application day. All animals appeared normal on Day 2 after treatment.
- Gross pathology:
- No significant pathological changes were found.
- Other findings:
- - Histopathology: liver: small intralobular/periportal infiltrates of round cells and congestion; kidneys: focal, subacute, interstitial nephritis in the cortex, focal proliferation of epithelial cells in the renal tubules and small interstitial infiltrates of round cells in the cortex; skin: slight hyperkeratosis
Any other information on results incl. tables
Details on test animals:
- Source: Charles River Wiga GmbH, Sulzfeld, Germany
The abraded skin of all animals appeared normal throughout the study period.
Histopathological examination revealed small intralobular/periportal infiltrates of round cells and congestion in the liver. In the kidneys, focal subacute, interstitial nephritis in the cortex, focal proliferation of epithelial cells in the renal tubules and small interstitial infiltrates of round cells in the cortex were observed. Furthermore, slight hyperkeratosis was found in skin tissues.
Evaluation of the histopathological findings:
A slight hyperkeratosis of the skin is an indication for minimal irritation on the application site. Small infiltrates of round cells in liver and kidneys as well as a slight focal interstitial nephritis are indications for small local infections as they can frequently be found in rats under conventional husbandry. In that connection, small focal proliferates of epithelial cells in the renal tubules were also found. The congestion is conditioned by the fact that the animals were not exsanguinated.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- In this acute dermal toxicity study a LD50 value > 2000 mg/kg bw in male and female rats was found.
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