Registration Dossier
Registration Dossier
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EC number: 235-795-5 | CAS number: 12738-64-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- The study is from the RAC oppinion of Benzoic acid and is indicated as the most reliable study on sensitisation. RAC oppinion reffering to data from Gerberick et al Toxicol 19:438-445 (1992).
Data source
Reference
- Reference Type:
- other: RAC oppinion
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- no
- Remarks:
- Study was performed before 1. of June 2008
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Benzoic acid
- EC Number:
- 200-618-2
- EC Name:
- Benzoic acid
- Cas Number:
- 65-85-0
- Molecular formula:
- C7H6O2
- IUPAC Name:
- benzoic acid
- Test material form:
- not specified
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA:J
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- other: acetone
- No. of animals per dose:
- 5
Results and discussion
In vivo (LLNA)
Results
- Key result
- Parameter:
- other: Not indicated
- Value:
- 0
- Test group / Remarks:
- 0/5 animals were sensitized
- Remarks on result:
- other:
- Remarks:
- Negative. The substance is not sensitising
Any other information on results incl. tables
No information on SI or EC3 is available
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Benzoic acid is not sensitising
- Executive summary:
The sensitizing activity of benzoic acid was tested in LLNA (Non-GLP, sim. to OECD 429) in CBA/J mice. Benzoic acid was dissolved in acetone. 0 out of 5 mice was senstised. The test was negative and showed that benzoic acid was not sensitising.
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