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Diss Factsheets
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EC number: 234-014-5 | CAS number: 10489-46-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Case report on only one individual, with limited reporting
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Occupational contact dermatitis caused by rhodium
- Author:
- Gomez de la Fuente E, Alvarez JG, Vicente FJ, Sols M, Naz E and Lopez-Estebaranz JL
- Year:
- 2 003
- Bibliographic source:
- American Journal of Contact Dermatitis 14, 172-175
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- Patch test performed on an individual with occupationally-associated dermatitis.
- GLP compliance:
- not specified
- Remarks:
- not applicable
Test material
- Reference substance name:
- rhodium sulfate
- IUPAC Name:
- rhodium sulfate
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): rhodium sulfate
- Substance type: no data
- Physical state: no data
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
- Isomers composition: no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 1
- Sex: female
- Age: 59
- Race: no data - Clinical history:
- - History of allergy or casuistics for study subject: no significant previous clinical history.
- Symptoms, onset and progress of the disease: 2-year pruriginous erythematous dermatitis on fingers and forearms, predominantly on first three digits of each hand
- Exposure history: worked in a goldsmith's workshop for 10 years, using an electrogalvanic device with a rhodium sulfate solution in dilute sulfuric acid (rhodium concentration 2.75 g/l).
- Aggravating factors both in home and workplace: Handled several metals including gold, silver, platinum, nickel and chromium. Dermatitis was said to improve upon absence from work for several weeks.
- Family history: no data
- Any other allergic or airway disorders: no data
- Smoking history: no data - Controls:
- None.
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test) with the Spanish Group for Research of Contact Dermatiis (GEIDC) series and a "metal series" from Chemotechnique Diagnostics (Malmo, Sweden) [nether series was further defined].
ADMINISTRATION
- Type of application: no data
- Description of patch: no data
- Vehicle / solvent: no data
- Concentrations: 2%
- Volume applied: no data
- Testing/scoring schedule: reactions read at 2 and 4 days [it is not clear whether this is after patch application or removal]
- Removal of test substance: no data
EXAMINATIONS
- Grading/Scoring system: including "++"; not further defined
- Statistical analysis: no data
Results and discussion
- Results of examinations:
- SYMPTOMS
- A reaction indicative of skin sensitisation was seen (positive, "++", not further defined, at days 2 and 4) for rhodium sulfate only.
RESULT OF CASE REPORT: after avoiding contact with rhodium solution, and protecting hands with gloves, great improvement was seen in the dermatitis. Occasional contact resulted in relapse of symptoms.
Applicant's summary and conclusion
- Conclusions:
- A case study reports an individual with occupational exposure to a rhodium sulfate solution, and a concurrent history of work-related dermatitis, displaying a reaction indicative of skin sensitisation following patch-testing with 2% rhodium sulfate.
- Executive summary:
A case report describes an individual with occupational exposure to a rhodium sulfate solution, and a concurrent history of work-related dermatitis.
A patch test with 2% rhodium sulfate, applied to the skin of the patient for an unspecified amount of time with reactions read after 2 and 4 days, indicated skin sensitisation. Dermatitis symptoms improved after changing working habits to avoid contact with rhodium sulfate.
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