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Diss Factsheets
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EC number: 236-599-2 | CAS number: 13446-49-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- in vivo study
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-07-10 to 1990-07-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, conducted and documented in accordance with GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted 12 May 1981
- Deviations:
- yes
- Remarks:
- , the test substance only was applied to 2.5 cm square of skin instead to approximately 6 cm square of skin
- GLP compliance:
- yes
- Remarks:
- The study report states that the study was conducted in compliance with Good Laboratory Practice Standards, e.g. by the United Kingdom Compliance Programme, Department of Health & Social Security 1986 and subsequent revision, Department of Health, 1989.
Test material
- Reference substance name:
- Diammonium dimolybdate
- EC Number:
- 248-517-2
- EC Name:
- Diammonium dimolybdate
- Cas Number:
- 27546-07-2
- IUPAC Name:
- Diammonium dimolybdate
- Details on test material:
- - Name of test material : ammonium dimolybdate
- Physical state: white crystalline powder
- Analytical purity: > 99.9 % (calculated based on Molybdenum content of 56.43%)
- Impurities (identity and concentrations): no relevant impurities (> 1.0 %)
- Purity test date: 1990-06-06
- Stability under test conditions: not determined
- Storage condition of test material: at ambient temperature
No further significant information on test material was stated.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: approximately 9 to 12 weeks
- Weight at study initiation: weight range 2.2 to 2.7 kg
- Housing: The rabbits were individually housed in metal cages with perforated floors.
- Diet: free access to SDS Standard Rabbit Diet
- Water: free access to tap water
- Acclimation period: The rabbits were acclimated to the laboratory environment, but the acclimatisation period was not stated.
ENVIRONMENTAL CONDITIONS
- Temperature: maintained at approximately 19 °C
- relative humidity: maintained at 30 - 70 %
- Air exchanges: maintained at approximately 19 air changes per hour
- Photoperiod (hrs dark / hrs light): 12 hrs/12hrs
No further significant information on test animals were given.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g amount of Ammonium molybdate
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5 ml distilled water
No further significant information was stated. - Duration of treatment / exposure:
- four hour period
- Observation period:
- Examination of treated skin was made on Day 1 (i.e. approximately 30 minutes after removal of the patches) and on days 2, 3 and 4. All animals were observed daily for signs of ill health or toxic signs.
- Number of animals:
- 6 female rabbits
- Details on study design:
- TEST SITE
- Area of exposure: Approximately 24 hours prior to application of the test substance, hair was removed with electric clippers from the dorso-lumbar region of each rabbit exposing an area of skin approximately 10 cm square.
- Type of wrap if used: A 2.5 cm square gauze pad was used. Each treatment site was occluded with "Elastoplast" elastic adhesive dressing.
REMOVAL OF TEST SUBSTANCE
- Washing: The treatment site was washed using water to remove any residual test substance.
- Time after start of exposure: At the end of the exposure period (Exposure period: 4 hours)
SCORING SYSTEM:
Grading and scoring of the dermal reactions were performed using the prescribed numerical scoring system as follows:
Erythema and eschar formation:
No erythema = 0
Very slight erythema (barely perceptible) = 1
Well-defined erythema = 2
Moderate to severe erythema = 3
Severe erythema (beet redness) to slight eschar formation (injuries in depth) = 4
Oedema formation:
No oedema = 0
Very slight oedema (barely perceptible) = 1
Slight oedema (edges of area well-defined by definite raising) = 2
Moderate oedema (raised approximately 1 millimetre) = 3
Severe oedema (raised more than 1 millimetre and extending beyond the area of exposure) = 4
No further significant information on study design was stated.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: Day 1 (i.e. approximately 30 minutes after removal of the patches) and on Days 2, 3 and 4
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No response to treatment in any animal throughout the observation period.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: Day 1 (i.e. approximately 30 minutes after removal of the patches) and on Days 2, 3 and 4
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No response to treatment in any animal throughout the observation period.
- Irritant / corrosive response data:
- There was no response to treatment in any animal throughout the observation period.
- Other effects:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A single semi-occlusive application of Ammonium dimolybdate to intact rabbit skin for four hours elicited no dermal irritation.
Ammonium dimolybdate does not require classification as a skin irritant according to directive 67/548/EEC or regulation 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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