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EC number: 215-164-0 | CAS number: 1308-87-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1963
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1963
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- The test item was injected into the stomach of mice in increasing quantities.
- GLP compliance:
- not specified
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- Highest dose was 10000 mg/kg bw. No information on lower doses.
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- >= 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- None, it was reported that no deleterious effect was observed when administering a dose of 10000 mg/kg bw.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Up to 10000 mg/kg bw (test item injected into the stomach of mice) has no apparent deleterious effects.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1963
Materials and methods
- Principles of method if other than guideline:
- The test item was administered to guinea pigs at a dose level of 2000 mg/kg every other day for a month via oral gavage. A control group was included.
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Didysprosium trioxide
- EC Number:
- 215-164-0
- EC Name:
- Didysprosium trioxide
- Cas Number:
- 1308-87-8
- Molecular formula:
- Dy2O3
- IUPAC Name:
- dysprosium(3+); oxygen(2-)
- Test material form:
- solid: particulate/powder
- Details on test material:
- No further information on test item available.
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Details on species / strain selection:
- No further data
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: gavage
- Details on route of administration:
- No data
- Vehicle:
- other: edulcorated starch paste
- Details on oral exposure:
- PREPARATION OF DOSING SOLUTIONS:
Test item dust in the required dose was mixed with edulcorated thick starch paste and delivered via syringe to the mouth of the animals.
VEHICLE
Justification for use and choice of vehicle (if other than water): Starch paste for palatability of test substance. - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- During the experiment, each animal received 16-18 g of test item.
- Duration of treatment / exposure:
- 30 days
- Frequency of treatment:
- Every other day.
Doses / concentrations
- Dose / conc.:
- 2 000 other: mg/kg bw, every other day
- No. of animals per sex per dose:
- No data
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- No data
- Positive control:
- No data
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Not specified
DETAILED CLINICAL OBSERVATIONS: Not specified
BODY WEIGHT: Not specified
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study):
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: Not specified
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: Not specified
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: Not specified
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): Not specified
OPHTHALMOSCOPIC EXAMINATION: Not specified
HAEMATOLOGY: Yes
- Time schedule for collection of blood: No data
- Anaesthetic used for blood collection: No data
- Animals fasted: No data
- How many animals: No data
- Parameters examined: Hemoglobin, erythrocytes and leukocytes, differential blood count; blood coagulability (prothrombin index)
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: No data
- Animals fasted: No data
- How many animals: No data
- Parameters checked: Study of the state of the liver and processes of protein metabolism: amino acids in blood serum, protein levels and enzyme levels in blood serum.
URINALYSIS: Yes
- Time schedule for collection of urine: No data
- Metabolism cages used for collection of urine: No data
- Animals fasted: No data
- Parameters examined: Study of state of the liver and processes of protein metabolism: amino acids in urine.
NEUROBEHAVIOURAL EXAMINATION: Not specified
IMMUNOLOGY: Not specified - Sacrifice and pathology:
- GROSS PATHOLOGY: Not specified
HISTOPATHOLOGY: Yes
- Microscopic investigation of the structure of the internal organs of animals killed after completion of dosing. - Other examinations:
- No data
- Statistics:
- Yes, no further data
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- no effects observed
- Description (incidence and severity):
- Statistical analysis of the blood data revealed no significant effects from the exposure to the test item.
No further data. - Clinical biochemistry findings:
- no effects observed
- Description (incidence and severity):
- Statistical analysis of the blood data revealed no significant effects from the exposure to the test item.
No further data. - Urinalysis findings:
- no effects observed
- Description (incidence and severity):
- No further data.
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- no effects observed
- Description (incidence and severity):
- Microscopic examination of internal organs revealed no significant findings. No further data.
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Details on results:
- No further data.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- >= 2 000 other: mg/kg bw, every other day
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
Target system / organ toxicity
- Critical effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: study not used for classification due to deficiencies of the study.
The degree of toxicity of the test item to guinea pigs over a 30 day exposure period was found to be negligible, when administering a dose of 2000 mg/kg bw every other day via oral gavage.
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