2,5-diphenyloxazole

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24th July 2017 to the 20th November 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Test guideline 3

Qualifier:

according to guideline

Guideline:

other: European Commission Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’ (2002).

Principles of method if other than guideline:

Intended to provide a procedure for the study of the airborne dust and the nature of the dust produced for water soluble compounds.

GLP compliance:

yes (incl. QA statement)

Type of method:

cascade impaction

Type of particle tested:

primary particle

Test material

Test material information

1

Reference substance name:

2,5-diphenyloxazole

EC Number:

202-181-3

EC Name:

2,5-diphenyloxazole

Cas Number:

92-71-7

Molecular formula:

C15H11NO

IUPAC Name:

2,5-diphenyl-1,3-oxazole

Test material form:

solid: crystalline

Details on test material:

Expiry date:01 February 2021
Storage conditions: Room temperature in the dark
Batch 21-16131

Specific details on test material used for the study:

Identification:
2,5-diphenyloxazole
Appearance/Physical state:
White crystalline powder
Batch:
21-16131
Purity:
99.9%
Expiry date:
01 February 2021
Storage conditions:
Room temperature, in the dark

Results and discussion

Particle size

Key result

Remarks on result:

not measured/tested

Particle size distribution at different passages

Particle size distribution at different passages 1

No.:

#1

Size:

< 100 µm

Distribution:

ca. 60.9 %

Particle size distribution at different passages 2

No.:

#2

Size:

< 10 µm

Distribution:

< 0.35 %

Particle size distribution at different passages 3

No.:

#3

Size:

< 5.5 µm

Distribution:

< 0.06 %

Any other information on results incl. tables

The overall results from the cascade impactor were taken as limit values due to the variation between the sampling positions; this gives a worst case scenario.

Too few particles were of a size less than 10.0 μm to allow accurate assessment of the mass median aerodynamic diameter.

Applicant's summary and conclusion

Conclusions:

The substance (2,5-diphenyloxazole) particle size was studied in accordance withEuropean Commission Guidance Document EUR 20268 via a GLP-certified laboratory. The study used the cascade impactor method and determined that the substance particle size was 60.9% less than 100 μm, <0.35 % less than 10μm and <0.06 % less than 5.5 μm respectively. Too few particles were of a size less than 10.0 μm to allow accurate assessment of the mass median aerodynamic diameter.

Executive summary:

The substance (2,5-diphenyloxazole) particle size was studied in accordance withEuropean Commission Guidance Document EUR 20268 via a GLP-certified laboratory. During the determinations, air was drawn through the cascade impactor by a vacuum pump at a flow rate of approximately 60 L/min for approximately 30 seconds. The air flow enters the impactor through a throat and inlet tube and then accelerates through the multiple stages. At each stage one or more nozzles direct the particle-laden airstream into a collection cup.

Particles larger than the cut size of a stage, impact onto the collection plate and stay in the collection cup. Smaller particles follow the airstream and are carried to the next stage. In succeeding stages the nozzles are smaller, the air velocity is higher and finer particles are collected. In the final stage the smallest particles are collected on a glass fibre filter. The mass of the artificial throat, collection cups and filter were recorded before and after each determination. The overall results from the cascade impactor were taken as limit values due to the variation between the sampling positions; this gives a worst case scenario.

The study used the cascade impactor method and determined that the substance particle size was 60.9% less than 100 μm, <0.35 % less than 10μm and <0.06 % less than 5.5 μm respectively. Too few particles were of a size less than 10.0 μm to allow accurate assessment of the mass median aerodynamic diameter.