Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: A scientific review (peer reviewed). No data on GLP.

Data source

Reference
Reference Type:
review article or handbook
Title:
Monographs on fragance raw materials: L-Borneol
Author:
Opdyke D L J
Year:
1978
Bibliographic source:
Food and Cosmetics Toxicology. Vol. 16, pp. 655-656.

Materials and methods

Principles of method if other than guideline:
No data on test method
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(1S-endo)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
EC Number:
207-353-1
EC Name:
(1S-endo)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
Cas Number:
464-45-9
Molecular formula:
C10H18O
IUPAC Name:
(1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
Test material form:
solid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
other: Not classified (CLP Regulation EC no. 1272/2008)
Conclusions:
The acute dermal LD50 value of the test substance was >2000 mg/kg bw in rabbits.
Executive summary:

According to the peer reviewed article, the acute dermal LD50 value of the test substance was >2000 mg/kg bw in rabbits.