Registration Dossier
Registration Dossier
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EC number: 225-582-5 | CAS number: 4940-11-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Just one animal was tested (at the limit dose level)
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-ethyl-3-hydroxy-4-pyrone
- EC Number:
- 225-582-5
- EC Name:
- 2-ethyl-3-hydroxy-4-pyrone
- Cas Number:
- 4940-11-8
- Molecular formula:
- C7H8O3
- IUPAC Name:
- 2-ethyl-3-hydroxy-4H-pyran-4-one
- Test material form:
- solid
1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Doses:
- 5 g/kg bw
- No. of animals per sex per dose:
- 1
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- 0/1
- Clinical signs:
- other: No skin irritation
Applicant's summary and conclusion
- Interpretation of results:
- other: not acute toxic
- Remarks:
- in accordance with EU CLP (EC 1272/2008 and its updates)
- Conclusions:
- The acute dermal LD50 for rabbits was determined at >5000 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study (MB 74-604), 1 rabbit was dermally exposed to the test item Ethyl Maltol at a dose of 5000 mg/kg bw.
The LD50 was >5000 mg/kg bw.
There was no mortality or indication of skin irritation.
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