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EC number: 282-162-4 | CAS number: 84100-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988-09-13 to 1988-09-20
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted 12 May 1981
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,3,3-trimethyl-3H-indole-5-carboxylic acid
- EC Number:
- 282-162-4
- EC Name:
- 2,3,3-trimethyl-3H-indole-5-carboxylic acid
- Cas Number:
- 84100-84-5
- Molecular formula:
- C12H13NO2
- IUPAC Name:
- 2,3,3-trimethyl-3H-indole-5-carboxylic acid
- Test material form:
- other: Moist presscake, white-faint reddish
Constituent 1
- Specific details on test material used for the study:
- - Other: beige color, pH approx. 4 (100 g/L H20)
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Ltd.
- Weight at study initiation: 2.9-3.4 kg
- Housing: individual cages (type III) stored in separate section in animal room
- Diet (e.g. ad libitum): ssniff K 4; 1 x 100-120 g/animal/day
- Water (e.g. ad libitum): tap water (7 am to 7 pm)
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 2
- Humidity (%): approx. 50
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg of moisted test substance
VEHICLE
- Amount(s) applied (volume or weight with unit): only small amounts for humidification
NEGATIVE CONTROL
- Amount(s) applied (volume or weight): only small amounts of vehicle (water only) - Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 1, 24, 48, 72 hours as well as 7 day after end of exposure
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 6 x 6 cm
- Type of wrap if used: adhesive plaster (Hansamed - Wundpflaster Hypoallergen (Beiersdorf No. 2342)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes (water)
- Time after start of exposure: 4 hrs
OBSERVATION TIME POINTS
(indicate if minutes, hours or days) 1, 24, 28, 72 hours as well as 7 days after end of exposure
SCORING SYSTEM:
- Method of calculation: DRAIZE-grades
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2, #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2, #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- All animals had a score of 0.0 for both erythema and edema during the entire observation period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Trimethylcarbonsäure was not irritating in the in vivo skin irritation test under the experimental conditions described in this report.
- Executive summary:
In a primary dermal irritation study performed in accordance with OECD Guideline 404 (Acute Dermal Irritation / Corrosion), adopted 12 May 1981, adult male albino rabbits (strain New Zealand White) were dermally exposed to 500 mg of humidified Trimethylcarbonsäure (vehicle: water) for 4 hours to 36 cm² body surface area. Animals then were observed for 7 days. Irritation was scored by the method of DRAIZE.
No irritation occurred during the observation period (DRAIZE grade 0 in all animals).
In this study, Trimethylcarbonsäure is not a dermal irritant.
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