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Diss Factsheets
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EC number: 204-100-7 | CAS number: 115-69-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Overall reporting of study is limited, but sufficient information to judge on hazard potential
- Justification for type of information:
- See attached (in chapter 13 of IUCLID) document with the justification for the category/read-across approach.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1175 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2-aminopropane-1,3-diol
- EC Number:
- 208-584-0
- EC Name:
- 2-aminopropane-1,3-diol
- Cas Number:
- 534-03-2
- Molecular formula:
- C3H9NO2
- IUPAC Name:
- 2-amino-1,3-propanediol
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Serinol (APD-1,3)
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): APD-1, 3
- Lot/batch No.: 227-124
- Analytical purity: No data
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Dosing solution was prepared by dissolving 5 g test material per 10 ml water (USP sterile water for injection).
- Doses:
- 5 g/kg bw
- No. of animals per sex per dose:
- 10 animals (sex not indicated)
- Control animals:
- no
- Details on study design:
- Animals dosed and then returned to cages for observation until day 14. Bodyweights were determined prior to dosing and on day of sacrifce (prior to euthenasia). All animals necropsied at sacrifice.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 4 out of 10
- Clinical signs:
- other: 10/10 animals displayed piloerection and lethargy
- Gross pathology:
- Discoloration of the kidneys, liver, spleen and small intestine and signs of hemorrhaging in the stomach observed in the 4 animals that died.
- Other findings:
- none
Any other information on results incl. tables
Four rats (4/10) died within 24 hours following administration of the Limit Dose of 5 g/kg. Abnormal clinical signs were observed in all (10/10) animals which included piloerection and lethargy. The four animals that died showed abnormal signs at gross necropsy including discoloration of the kidneys, liver, spleen and small intestine and signs of hemorrhaging in the stomach.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance, APD-1, 3 LOT #: 227-124, was evaluated for its potential to produce death following oral administration at a dose of 5 g/kg in male and female Sprague- Dawley rats. Based on the mortality (4/10 animals) in the Limit Test, the test substance is not classified for acute oral toxicity.
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