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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from safety assessment report

Data source

Reference
Reference Type:
secondary source
Title:
Reports of the Scientific Committee on Cosmetology (seventh series)
Author:
Commission of the European Communities
Year:
1988
Bibliographic source:
Directorate-General Environment, Consumer Protection and Nuclear Safety- Commission of the European Communities- Brussels Luxembourg, 1988.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
An eye irritation study was conducted to determine the eye irritation potential of chemical Basic Violet 1 (CAS no: 8004-87-3).
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Basic violet 1
EC Number:
616-846-4
Cas Number:
8004-87-3
Molecular formula:
C24H28N3
IUPAC Name:
Basic violet 1
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report):Basic Violet 2
- Molecular formula :unspecified
- Molecular weight :358.5062 g/mol
- Substance type:Organic
- Physical state:solid
-InChI:1S/C24H28N3/c1-25-21-12-6-18(7-13-21)24(19-8-14-22(15-9-19)26(2)3)20-10-16-23(17-11-20)27(4)5/h6-17,25H,1-5H3/q+1
- Smiles: CNc1ccc(cc1)[C+](c2ccc(cc2)N(C)C)c3ccc(cc3)N(C)C
Specific details on test material used for the study:
- Name of test material (as cited in study report):Basic Violet 2
- Molecular formula :unspecified
- Molecular weight :358.5062 g/mol
- Substance type:Organic
- Physical state:solid
-InChI:1S/C24H28N3/c1-25-21-12-6-18(7-13-21)24(19-8-14-22(15-9-19)26(2)3)20-10-16-23(17-11-20)27(4)5/h6-17,25H,1-5H3/q+1
- Smiles: CNc1ccc(cc1)[C+](c2ccc(cc2)N(C)C)c3ccc(cc3)N(C)C

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No Data available

Test system

Vehicle:
other: Aqueous solution
Controls:
not specified
Amount / concentration applied:
0.1%
Duration of treatment / exposure:
No Data available
Observation period (in vivo):
No Data available
Duration of post- treatment incubation (in vitro):
No Data available
Number of animals or in vitro replicates:
No Data available
Details on study design:
No Data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No eye irritation was observed.

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The chemical Basic Violet 1 (CAS no: 8004-87-3) was considered to be not irritating to the rabbits’ eye at when tested at dose of 0.1% aqueous solution.
Executive summary:

An eye irritation study was conducted to determine the eye irritation potential of chemical Basic Violet 1 (CAS no: 8004-87-3).

 

No eye ocular lesions were observed when the rabbits were tested at0.1% aqueous solution of test substance. Hence the chemical Basic Violet 1 (CAS no: 8004-87-3) was considered to be not irritating to the rabbits’ eye.