Registration Dossier
Registration Dossier
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EC number: 229-962-1 | CAS number: 6864-37-5
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
- Principles of method if other than guideline:
- see details in remarks on material and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine)
- EC Number:
- 229-962-1
- EC Name:
- 2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine)
- Cas Number:
- 6864-37-5
- Molecular formula:
- C15H30N2
- IUPAC Name:
- 4-[(4-amino-3-methylcyclohexyl)methyl]-2-methylcyclohexan-1-amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 5 injections
- Frequency of treatment:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
ca. 47, 95, 189 mg/kg bw/injection (50, 100, 200 µl/kg bw/injection)
- No. of animals per sex per dose:
- 5 (no gender stated)
- Control animals:
- no
- Details on study design:
- Post-exposure period: 16 days
Results and discussion
Effect levels
- Sex:
- not specified
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
All five animals of the high dose group died; no deaths were observed at the mid and low dose level. After approximately 10 days, the test substance perforated the skin after the application and was present at the skin surface.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
