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Diss Factsheets
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EC number: 203-424-6 | CAS number: 106-69-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26.01.1989 to 20.02.1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Guideline 84/449/EEC
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Hexane-1,2,6-triol
- EC Number:
- 203-424-6
- EC Name:
- Hexane-1,2,6-triol
- Cas Number:
- 106-69-4
- Molecular formula:
- C6H14O3
- IUPAC Name:
- hexane-1,2,6-triol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: White russian (Albino)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Strain: Rabbit / White Russian
- Breeder: ASTA Pharma AG, D-4800 Bielefeld 14
- Number and sex: 3 animals (2 males and 1 females)
- Body weigth: males 2.43 or 2.54 kg, female 3.05 kg
- Age: 11 month
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS:
- Diet: Standard diet, ssniff K, "Special Diet for Rabbits" supplied by ssniff Spezialfutter GmbH, D-4770 Soestad libitum
- Water: tab water ad libitum
- Housing individually in stainless steel cages
- Temperature: 21-22°C
- Rel. Humidity: 45-60%
- Light/dark period: 12/12h
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 hours (occlusive patch)
- Observation period:
- Observation Times: 1, 24, 48 and 72 hours after removal of the patches
Duration of the Observation Period: 3 days p. appl. - Number of animals:
- 2 males and 1 female
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
Any other information on results incl. tables
Systemic-toxic effects did not occur after dermal application of the test substance. The general condition of the test animals was not affected.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Following 4-hour occlusive treatment with 0.5 mL undiluted test item to the intact skins of three rabbits no signs of irritation were oberved. Neither erythema nor edema could be detected during the observation period. Thus, 1,2,6-Hexantriol is considered to be non-irritant in this test system, and according to Regulation (EC) 1272/2008 the data are conclusive but not sufficient for classification.
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