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EC number: 300-346-5 | CAS number: 93925-43-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 - 27 Oct 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- adopted Feb 2002
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Version / remarks:
- May 2008
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Version / remarks:
- 2002
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Ministry of Agriculture, Forestry and Fisheries, No 8147
- Version / remarks:
- Nov 2000
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Food and Consumer Product Safety Authority (VWA), Utrecht, The Netherlands
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Silicic acid (H4SiO4), tetraethyl ester, reaction products with bis(acetyloxy)dioctylstannane
- EC Number:
- 300-346-5
- EC Name:
- Silicic acid (H4SiO4), tetraethyl ester, reaction products with bis(acetyloxy)dioctylstannane
- Cas Number:
- 93925-43-0
- Molecular formula:
- C4H8O2, C20H44O4SiSn, C24H52O6SiSn, C40H84O8SiSn2, C60H128O12Si2Sn3, C80H172O16Si3Sn4, C100H216O20Si4Sn5
- IUPAC Name:
- Silicic acid (H4SiO4), tetraethyl ester, reaction products with bis(acetyloxy)dioctylstannane
Constituent 1
- Specific details on test material used for the study:
- TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: The formulations (w/w) were prepared within 4 hours prior to dosing. Homogeneity was accomplished to a visually acceptable level. Adjustment was made for specific gravity of the vehicle and test substance. In order to obtain homogeneity, the test substance formulations were heated in a water bath with a maximum temperature of 79.1ºC for a maximum of 40 minutes. The test substance formulations were allowed to cool down to a temperature of maximally 40ºC prior to dosing.
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Crl:WI (Han) (outbred, SPF-Quality)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Sulzfeld, Germany
- Females nulliparous and non-pregnant: yes
- Age at study initiation: 11 weeks
- Weight at study initiation: group 1: 171 ± 22 g; group 2: 183 ± 10 g
- Fasting period before study: animals were fasted overnight prior to administration of the test substance
- Housing: group housing of 3 animals per cage in labeled Makrolon cages (MIV type; height 18 cm.) containing sterilized sawdust as bedding material and paper as cage enrichment.
- Diet: SM R/M-Z, pelleted, (Ssniff Spezialdiäten GmbH, Soest, Germany),ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.0 ± 3.0 (actual range: 19.3 – 21.2)
- Humidity (%): 40 - 70 (actual range 44 - 73)
- Air changes (per hr): approximately 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: dehydrated corn oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 females (3 females dosed per step in 2 steps)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed twice daily for mortaility; individual body weights were determined on days 1 (pre-administration), 8, 15 and prior to sacrifice.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured during the study period.
- Clinical signs:
- other: Hunched posture was observed in 6/6 animals on Day 1-2, and recurred in 6/6 animals on Day 5 or 7, persisting until Day 11 in 5/6 and until Day 14 in 1/6. Piloerection was noted in 3/6 animals on several or all days in the period from Day 7-11. A lean ap
- Gross pathology:
- No substance-related findings.
Any other information on results incl. tables
Table 1 Clinical signs
Test Days | 1 | 1 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
Hours after dosing | 0 | 2 | 4 | ||||||||||||||
Animal 1 | |||||||||||||||||
Hunched posture | - | 1 | 1 | - | - | - | - | - | 1 | 1 | 1 | 1 | 1 | - | - | - | - |
Animal 2 | |||||||||||||||||
Hunched posture | - | 1 | 1 | - | - | - | - | - | - | - | 1 | 1 | 1 | - | - | - | - |
Animal 3 | |||||||||||||||||
Hunched posture | - | 1 | 1 | 1 | - | - | - | - | - | - | 1 | 1 | 1 | - | - | - | - |
Animal 4 | |||||||||||||||||
Hunched posture | 1 | 1 | 1 | 1 | - | - | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | - |
Piloerection | - | - | 1 | - | - | - | - | - | 1 | 1 | 1 | 1 | 1 | - | - | - | - |
Lean | - | - | - | - | - | - | - | - | - | 1 | 1 | 1 | 1 | 1 | 1 | 1 | - |
Animal 5 | |||||||||||||||||
Hunched posture | 1 | 1 | 1 | 1 | - | - | - | - | 1 | 1 | 1 | 1 | 1 | - | - | - | - |
Piloerection | - | - | - | - | - | - | - | - | 1 | 1 | - | - | 1 | - | - | - | - |
Animal 6 | |||||||||||||||||
Hunched posture | 1 | 1 | 1 | 1 | - | - | 1 | 1 | 1 | 1 | 1 | 1 | 1 | - | - | - | - |
Piloerection | - | - | - | - | - | - | 1 | 1 | 1 | 1 | - | - | - | - | - | - | - |
Lean | - | - | - | - | - | - | - | - | - | 1 | 1 | 1 | 1 | - | - | - | - |
1 = Max Grade of clinical signs
Table 2 Body weights (gram)
Days | 1 | 8 | 15 |
Animal 1 | 146 | 146 | 175 |
Animal 2 | 188 | 200 | 215 |
Animal 3 | 178 | 197 | 203 |
Mean ± SD | 171 ± 22 | 181 ± 30 | 198 ± 21 |
Animal 4 | 181 | 151 | 170 |
Animal 5 | 194 | 201 | 216 |
Animal 6 | 174 | 158 | 201 |
Mean ± SD | 183 ± 10 | 170 ± 27 | 196 ± 23 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
- Conclusions:
- CLP: not classified
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