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EC number: 236-293-9 | CAS number: 13283-01-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No data is available for Tungsten hexachloride (target substance). Thus, available data from Sodium tungstate and its dihydrate (source substances) was used in a read-across approach. In a subchronic repeated dose toxicity study with focus on the male reproductive system, Sodium tungstate dihydrate was administered daily to male Wistar rats by oral gavage at dose levels of 0 and 50 mg/kg bw/day for a total of 60 days. Results in the study did not indicate that Sodium tungstate dehydrate exposure resulted in direct male reproductive toxicity in the rat. Moreover, effects on the reproductive system were assessed in a study conducted similar to the Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Study (OECD 422) (see IUCLID section 7.8.2, McInturf 2008). In this study, Sodium tungstate dihydrate was administered to 40 SD rats/sex/dose by gavage at dose levels of 0, 5, and 125 mg/kg bw/day through mating, gestation, and weaning (PND 0-20). The NOAEL for reproductive/developmental toxicity can be considered to be 125 mg/kg/day (highest dose) based on the lack of significant effects. The tests were selected to provide a screening-level assessment of a range of neurobehavioral capacities in Sodium tungstate exposed dams and their offspring. In an updated report (see IUCLID section 7.8.2, McInturf 2011) it was confirmed that daily administration of the source substance produced no overt evidence of toxicity and had no apparent effect on mating success or offspring physical development.
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 125 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- comparable to guideline study
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No data is available for Tungsten hexachloride (target substance). Thus, available data from Sodium tungstate and its dihydrate (source substances) was used in a read-across approach.
Due to a lower water solubility of Tungsten hexachloride compared to the source substances the resulting bioavailability (toxicity potential) would also be expected to be lower. Therefore, the read across to the source substances Sodium tungstate and its dihydrate is adequately protective. For justification of read-across please refer to the read-across report attached to IUCLID section 13.
In a subchronic repeated dose toxicity study with focus on the male reproductive system, Sodium tungstate dihydrate was administered daily to male Wistar rats by oral gavage at dose levels of 0 and 50 mg/kg bw/day for a total of 60 days. Results in the study did not indicate that Sodium tungstate dehydrate exposure resulted in direct male reproductive toxicity in the rat.
Moreover, effects on the reproductive system were assessed in a study conducted similar to the Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Study (OECD 422) (see IUCLID section 7.8.2, McInturf 2008). In this study, Sodium tungstate dihydrate was administered to 40 SD rats/sex/dose by gavage at dose levels of 0, 5, and 125 mg/kg bw/day through mating, gestation, and weaning (PND 0-20). The NOAEL for reproductive/developmental toxicity can be considered to be 125 mg/kg/day (highest dose) based on the lack of significant effects. The tests were selected to provide a screening-level assessment of a range of neurobehavioral capacities in Sodium tungstate exposed dams and their offspring. In an updated report (see IUCLID section 7.8.2, McInturf 2011) it was confirmed that daily administration of the source substance produced no overt evidence of toxicity and had no apparent effect on mating success or offspring physical development.
Effects on developmental toxicity
Description of key information
No data is available for Tungsten hexachloride (target substance). Thus, available data from Sodium tungstate and its dihydrate (source substances) was used in a read-across approach. Effects on the reproductive/developmental system were assessed in a study conducted similar to the Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Study (OECD 422) (see IUCLID section 7.8.2, McInturf 2008). In this study, Sodium tungstate dihydrate was administered to 40 SD rats/sex/dose by gavage at dose levels of 0, 5, and 125 mg/kg bw/day through mating, gestation, and weaning (PND 0-20). The NOAEL for reproductive/developmental toxicity can be considered to be 125 mg/kg/day (highest dose) based on the lack of significant effects. The tests were selected to provide a screening-level assessment of a range of neurobehavioral capacities in Sodium tungstate exposed dams and their offspring. In an updated report (see IUCLID section 7.8.2, McInturf 2011) it was confirmed that daily administration of the source substance produced no overt evidence of toxicity and had no apparent effect on mating success or offspring physical development.
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Limit test:
- no
- Details on maternal toxic effects:
- REPRODUCTIVE PERFORMANCE (PARENTAL ANIMALS):
A statistically significant difference was found in the dams, average gestation duration was longer for the 125 mg/kg/day dose group than for the control and 5 mg/kg/day groups. Average gestational weight gain did not differ across treatments.
OTHER EFFECTS
Maternal Retrieval and Watermaze Navigation: No effects of sodium tungstate exposure at either dose were found in the dams for latency of maternal retrieval, or watermaze navigation latency or distance traveled.
Acoustic Startle/Prepulse Inhibition: For acoustic startle/prepulse inhibition, no significant main effects or interactions related to dose were found for any of the dependent measures.
Spontaneous Locomotor Activity: Exposure effects in the dams were detected for some of the measures of spontaneous locomotor activity. Specifically, dams treated with the low dose showed significantly more ambulatory time and distance travelled, as well as decreased time in stereotypies as compared to both controls and the high dose. In contrast, dams in the high dose demonstrated significantly less time resting, and more time in stereotypic movements than the vehicle controls or low dose group. - Dose descriptor:
- NOAEL
- Effect level:
- 125 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Basis for effect level:
- other: no adverse effects observed
- Abnormalities:
- not specified
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects: no effects
Details on embryotoxic / teratogenic effects:
There were no differences in average number of pups born.
All pups were inspected for physical birth defects, including missing digits, however, none were found.
The high dose group demonstrated a greater number of ultrasonic distress vocalizations when separated from the dam and littermates.
Righting reflex: For righting reflex, a significant effect of sex was found (p <0.05) where males were faster (9.6±1.3 s) than females (14.5 ± 1.6 s). No significant effects related to dose were found. - Dose descriptor:
- NOAEL
- Effect level:
- 125 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Basis for effect level:
- other: no adverse effects observed
- Abnormalities:
- not specified
- Developmental effects observed:
- not specified
- Conclusions:
- The tests were selected to provide a screening-level assessment of a range of neurobehavioral capacities in sodium tungstate exposed dams and their offspring. The tests evaluated reflexive responding, emotionality and spatial learning and memory. Exposure-related effects were observed both in the dams and developing pups, and for low and high dose exposures. Overall, the results of this study suggest pre- and postnatal oral exposure to sodium tungstate may produce subtle neurobehavioral effects in offspring related to motor activity and emotionality. The NOAEL for developmental toxicity was deemed to be 125 mg/kg/day.
- Executive summary:
In a Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Study sodium tungstate was administered to 40 SD rats/sex/dose by gavage at dose levels of 0, 5, and 125 mg/kg bw/day through mating, gestation, and weaning (PND 0-20). A statistically significant difference was found for one of the treatment groups on measures of reproductive toxicity. In the dams, average gestation duration was longer for the 125 mg/kg/day dose group than for the control and 5 mg/kg/day groups. Average gestational weight gain did not differ across treatments. In the pups, there were no differences in average number of pups born.
The NOAEL for the F1 generation was 125 mg/kg/day based on the lack of significant effects.
The Reproduction/Developmental toxicity study in the rat is classified acceptable but does not completely satisfies the guideline requirements for a developmental toxicity study (OPPTS 870.3700; OECD 414) in rodents, as no detailed examination of soft tissue or skeleton of the fetuses were conducted.
This information is used in a read-across approach in the assessment of the target substance.
For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
Reference
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 125 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- comparable to guideline study
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No data is available for Tungsten hexachloride (target substance). Thus, available data from Sodium tungstate and its dihydrate (source substances) was used in a read-across approach.
Due to a lower water solubility of Tungsten hexachloride compared to the source substances the resulting bioavailability (toxicity potential) would also be expected to be lower. Therefore, the read across to the source substances Sodium tungstate and its dihydrate is adequately protective. For justification of read-across please refer to the read-across report attached to IUCLID section 13.
Effects on the reproductive/developmental system were assessed in a study conducted similar to the Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Study (OECD 422) (see IUCLID section 7.8.2, McInturf 2008). In this study, Sodium tungstate dihydrate was administered to 40 SD rats/sex/dose by gavage at dose levels of 0, 5, and 125 mg/kg bw/day through mating, gestation, and weaning (PND 0-20). The NOAEL for reproductive/developmental toxicity can be considered to be 125 mg/kg/day (highest dose) based on the lack of significant effects. The tests were selected to provide a screening-level assessment of a range of neurobehavioral capacities in Sodium tungstate exposed dams and their offspring. In an updated report (see IUCLID section 7.8.2, McInturf 2011) it was confirmed that daily administration of the source substance produced no overt evidence of toxicity and had no apparent effect on mating success or offspring physical development.
Justification for classification or non-classification
Based on the available data from the read-across partner Sodium tungstate and its dihydrate, the target substance Tungsten hexachloride does not warrant classification for reproductive toxicity in accordance to CLP regulation 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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