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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 946-565-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- To be completed
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- - Test item: REACH substance = freeze-dried commercial product
- Analytical purity: 97.2%
- Purity test date: 08 March 2017
- Lot:bacth No.: WI6G16X07 after drying
- Expiration date of the lot/batch: 16 July 2018
- Appearance: Off-white to yellow crystals
- Storage: At room temperature - Key result
- Melting / freezing pt.:
- >= 137.7 - <= 141.8 °C
- Atm. press.:
- 1 013 hPa
- Decomposition:
- yes
- Conclusions:
- The melting point of the test item was determined to be in the range 137.7-141.8°C.
- Executive summary:
The melting point of the test item (= REACH substance) was determined in a GLP-compliant study performed in accordance with EC A.1 method and OECD Guideline No. 102, using Differential Scanning Calorimetry (DSC). The melting point of the test item was determined to be in the range 137.7-141.8°C.
Reference
Preliminary test
Starting at 225°C, the weight of the sample decreased significantly. At 346°C, the sample weight had decreased by 25%. After the experiment, a black molten residue remained in the sample container (original colour: off-white to yellow). The change of the colour indicated reaction and/or decomposition of the test item.
Main study
In Experiment 1, an endothermic peak was observed between 25°C and 100°C. The endothermic effect was due to evaporation of volatile components (the test item contains 2.8% water). An endothermic peak was observed between 100°C and 200°C. The extrapolated onset temperature of the peak was 137.708°C. The endothermic effect was most likely obtained due to melting and reaction and/or decomposition of the test item. From 200°C, an endothermic peak followed by an exothermic peak were observed. The effects were due to reaction and/or decomposition of the test item. After the experiment, a brown molten residue remained in the sample container.
In order to investigate the melting peak, Experiment 2 was stopped directly after the melting peak. The extrapolated onset temperature was 141.808°C. After the experiment, a beige molten residue remained in the sample container (original colour: off-white to yellow). It demonstrated that melting was the reason for the endothermic effect. Based on the weight loss observed at 150°C during the preliminary test it is most likely that reaction and/or decomposition occurred during melting of the test item. A change in colour was not significant as an indication of the decomposition.
In order to investigate the melting peak, a lower heating rate of 5°C/minute was applied in Experiment 3. The extrapolated onset temperature of the melting peak could not be determined. A smaller melting peak was obtained due to reaction and/or decomposition which had occurred at lower temperatures. It demonstrated that reaction and/or decomposition occurred during melting of the test item. After the experiment, a beige molten residue remained in the sample container.
Experiment 4 was performed as a duplicate of Experiment 2. Similar results as in Experiment 2 were obtained. The extrapolated onset of the melting peak was 140.052°C. After the experiment, a beige molten residue remained in the sample container.
Since reaction and/or decomposition was observed during melting a high deviation was found between the extrapolated onset temperatures. Therefore a melting range is given instead of a melting temperature. The melting range was determined as the lowest and highest melting temperature of Experiment 1 (137.708°C), Experiment 2 (141.808°C) and Experiment 4 (140.052°C).
Description of key information
The melting point of the test item (= REACH substance) was determined in a GLP-compliant study performed in accordance with EC A.1 method and OECD Guideline No. 102, using Differential Scanning Calorimetry (DSC). The melting point of the test item was determined to be in the range 137.7-141.8°C.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 137.7 °C
Additional information
The melting point of the test item was determined in one GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.