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EC number: 817-668-1 | CAS number: 667899-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From June 1994 to August 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- read-across
- Justification for type of information:
- Refer to the section 13 for details on the read across justification. The skin irritation study with the read across substance is considered sufficient to fulfil the information requirements as further explained in the provided endpoint summary.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- limited documentation but relevant data given
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- yes
- Duration of treatment / exposure:
- 4 h
- Observation period:
- Time points: 30 - 60 min, 24, 48 and 72 h
- Number of animals:
- 3 females
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- The only sign of irritation was a slight transient erythema observed in all three rabbits 30-60 min after patch removal.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the study conditions, the substance was non-irritating to rabbit skin.
- Executive summary:
A study was conducted to determine the skin irritation potential of the read-across substance CAS 7299 -99 -2 in rabbits according to a method similar to OECD Guideline 404. The test substance was applied to the shaved skin of 3 female rabbits under a semi-occlusive patch for 4 h. Upon patch removal, the exposed skin was observed for signs of skin irritation at 30 -60 min, 24, 48 and 72 h. The only sign of irritation was a slight transient erythema observed in all three rabbits 30 -60 min after patch removal. Under the study conditions, the test substance was non-irritating to rabbit skin (Zeneca, 1994).
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- From June 1994 to August 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Read-across
- Justification for type of information:
- The supporting skin irritation study is considered sufficient to fulfil the information requirement.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 4924 - 5154 g
- Sex: Female - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 mL of the test sample
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Observation time points: 30 - 60 min, 24, 48, 72 and 96 h
- Number of animals:
- Three females
- Details on study design:
- The test sample was applied to a 2.5 cm square area on the shaved left flank of the dorso-lumbar area.
REMOVAL OF TEST SUBSTANCE
- Washing: cleansing with clean warm water
- Time after start of exposure: 4 h (upon removal of the dressing)
SCORING SYSTEM: Draize scoring system - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- ca. 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- ca. 1.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 d
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- ca. 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 d
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- ca. 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- ca. 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- ca. 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the study conditions, the substance was not considered to be irritating to rabbit skin.
- Executive summary:
A study was conducted to determine the skin irritation potential of the read-across substance CAS 68424 -31 -7 according to a method similar to OECD Guideline 404. Three female New Zealand White albino rabbits were used in the study. Approximately 0.5 mL of the test substance was applied to a 2.5 cm square area on the shaved left flank of the dorso-lumbar region of each animal under a semi-occlusive dressing for 4 h. Upon removal of the dressing, the skin was cleansed with clean warm water. The application sites were assessed for signs of erythema and oedema and scored according to the Draize scale at approximately 30 -60 min, 24, 48, 72 and 96 h after removal of the dressings. Very slight to well-defined erythema and very slight oedema were observed up to 72 h after application and the signs were resolved 96 h after application. Under the study conditions, the substance was not considered to be irritating to rabbit skin (Robinson, 1991).
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- RA study
- Justification for type of information:
- Refer to the section 13 of IUCLID dataset for details on the read across justification. The eye irritation study with the read across substance is considered sufficient to fulfil the information requirements as further explained in the provided endpoint summary.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Observation period (in vivo):
- 3 days
- Number of animals or in vitro replicates:
- 3 animals
- Details on study design:
- SCORING SYSTEM: Draize
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- All signs of irritation had completely regerssed three days after instillation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the study conditions, the substance was not considered to be irritating to the rabbit eye.
- Executive summary:
A study was conducted to determine the eye irritation potential of the read-across substance CAS 7299 -99 -2 according to a method similar to OECD Guideline 405. Three New Zealand White rabbits were used in the study. After instillation of the test substance into eyes of rabbits, the irritation effects were observed at 24, 48 and 72 h. Scoring of the irritation reactions was performed according to the Draize scale. Apart from conjunctival redness in all three animals (which resolved within 72 h) and chemosis in one animal (which resolved within 48 h), no other sign of irritation could be observed. Under the study conditions, the substance was not considered to be irritating to the rabbit eye (Duerden, 1994).
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- RA study
- Justification for type of information:
- The supporting eye irritation study is considered sufficient to fulfil the information requirement.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3556-4556 g - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
- Concentration (if solution): pure- single application without washing - Duration of treatment / exposure:
- No Data
- Observation period (in vivo):
- 3 d
- Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- SCORING SYSTEM: Draize scoring system
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- No corneal or iridial effects were observed. Conjunctival effects included slight redness (1 animal) and slight discharge (1 animal) and were transiently seen approximately 1 h after dosing.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the study conditions, the substance was not considered to be irritating to rabbit eyes.
- Executive summary:
A study was conducted to determine the eye irritation potential of the read-across substance CAS 68424 -31 -7 according to a method similar to OECD Guideline 405. Three female New Zealand White rabbits were used in the study. 0.1 mL of the test substance was instilled into the conjunctival sac of the left eye of each rabbit. During an observation period of up to three days, the ocular reactions to the test substance were scored according to Draize scale. No treatment-related corneal or iridial effects were observed. Conjunctival effects included slight redness (one animal) and slight discharge (one animal) seen approximately one hour after dosing. No other signs of irritation were observed. Under the study conditions, the substance was not considered to be irritating to rabbit eye (Robinson, 1991).
Referenceopen allclose all
Key scores for labelling
Lesion | 16 | 17 | 18 |
Corneal opacity | 0 | 0 | 0 |
Iritis | 0 | 0 | 0 |
Conj redness | 0.33 | 0.67 | 0.67 |
Chemosis | 0.33 | 0 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
A study was conducted to determine the skin irritation potential of the read-across substance CAS 7299 -99 -2 in rabbits according to a method similar to OECD Guideline 404. The test substance was applied to the shaved skin of 3 female rabbits under a semi-occlusive patch for 4 h. Upon patch removal, the exposed skin was observed for signs of skin irritation at 30-60 min, 24, 48 and 72 h. The only sign of irritation was a slight transient erythema observed in all three rabbits 30-60 min after patch removal. Under the study conditions, the substance was non-irritating to rabbit skin (Duerden, 1994).
A supporting study was conducted to determine the skin irritation potential of the read-across substance CAS 68424 -31 -7 according to a method similar to OECD Guideline 404. Three female New Zealand White albino rabbits were used in the study. Approximately 0.5 mL of the test substance was applied to a 2.5 cm square area on the shaved left flank of the dorso-lumbar region of each animal under a semi-occlusive dressing for 4 h. Upon removal of the dressing, the skin was cleansed with clean warm water. The application sites were assessed for signs of erythema and oedema and scored according to the Draize scale at approximately 30 -60 min, 24, 48, 72 and 96 h after removal of the dressings. Very slight to well-defined erythema and very slight oedema were observed up to 72 h after application and the signs were resolved 96 h after application. Under the study conditions, the substance was not considered to be irritating to rabbit skin (Robinson, 1991).
Eye irritation:
A study was conducted to determine the eye irritation potential of the read-across substance CAS 7299 -99 -2 according to a method similar to OECD Guideline 405. Three New Zealand White rabbits were used in the study. After instillation of the test substance into eyes of rabbits, the irritation effects were observed at 24, 48 and 72 h. Scoring of the irritation reactions was performed according to the Draize scale. Apart from conjunctival redness in all three animals (which resolved within 72 h) and chemosis in one animal (which resolved within 48 h), no other sign of irritation could be observed. Under the study conditions, the substance was not considered to be irritating to the rabbit eye (Duerden, 1994).
A supporting study was conducted to determine the eye irritation potential of the read-across substance CAS 68424 -31 -7 according to a method similar to OECD Guideline 405. Three female New Zealand White rabbits were used in the study. 0.1 mL of the test substance was instilled into the conjunctival sac of the left eye of each rabbit. During an observation period of up to three days, the ocular reactions to the test substance were scored according to Draize scale. No treatment-related corneal or iridial effects were observed. Conjunctival effects included slight redness (one animal) and slight discharge (one animal) seen approximately one hour after dosing. No other signs of irritation were observed. Under the study conditions, the substance was not considered to be irritating to rabbit eye (Robinson, 1991).
Justification for classification or non-classification
Based on the in vivo skin and eye irritation studies in rabbits with the read-across substances, the substance does not warrant any classification according to the EU CLP (EC 1272/2008) criteria.
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