Registration Dossier
Registration Dossier
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EC number: 223-620-5 | CAS number: 3982-82-9
Endpoint summary
Administrative data
Description of key information
The key study for skin irritation, conducted according to OECD TG 404, and in compliance with GLP, reports the test material to be not irritating to rabbit skin (LPT, 2002). The key study for eye irritation, conducted according to OECD TG 405, and in compliance with GLP, reports the test material to be not irritating to eyes (LPT, 2002).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key study for skin irritation, conducted according to OECD TG 404, and in compliance with GLP, reports the test material to be not irritating to rabbit skin (LPT, 2002).
Following 4-hour dermal application of 0.5 mL of test material onto the skin of 3 rabbits, kept in contact with the skin under semi-occlusive dressing, no erythema or oedema were observed in any of the animals during the 14-day study period. No signs of systemic toxicity were noted in any of the animals.
A supporting skin irritation study was available, conducted according to OECD TG 404, and in compliance with GLP, which also reports the test material to be not irritating to rabbit skin (DCC, 2000).
Following 4-hour dermal application of 0.5 mL of test material onto the skin of 3 female rabbits, kept in contact with the skin under semi-occlusive dressing, well-defined erythema was observed in one animal, which was fully reversible within 10 days. No erythema was observed in the rest of the animals. Oedema was not evident in any of the test animals. No signs of systemic toxicity were noted in any of the animals during the 10-day observation period.
The key study for eye irritation, conducted according to OECD TG 405, and in compliance with GLP, reports the test material to be not irritating to eyes (LPT, 2002).
Following a single instillation of 0.1 mL of test material into the eyes of 3 rabbits, grade 1 corneal opacity was observed in 2 of the animals, which was fully reversible within 48 hours. The iris and conjunctivae were not affected by the test substance. No other signs of systemic toxicity were noted during the observation period.
A supporting eye irritation study was available, conducted according to OECD TG 405, and in compliance with GLP, which also reports the test material to be not irritating to rabbit eyes (DCC, 2000).
Following a single instillation of 0.1 mL of test material into the eyes of 3 rabbits, grade 1 conjunctival redness was observed in all of the animals, which was fully reversible within 48 hours. The cornea and iris were not affected by the test substance. No other signs of systemic toxicity were noted during the observation period.
Justification for classification or non-classification
Based on the available in vivo data for 1,3,3,5-tetramethyl-1,1,5,5-tetraphenyltrisiloxane, no classification for skin and eye irritation is required according to Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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