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EC number: 217-703-5 | CAS number: 1934-75-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an acute oral toxicity study using albino rats, the oral LD50 was 725 mg/kg bw (95% CL: 605 -875 mg/kg bw) in males and 775.0 mg/kg bw in females (95% CL: 670.0 - 895.0 mg/kg bw). The study has been conducted before implementation of GLP.
Additionally, handbook data indicate that the oral LD50 in mice was about 1000 mg/kg and the intraperitoneal LD50 610 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976-01-28
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable for assessment but without detailed documentation. Study report meets basic scientific principles. Study was conducted prior to GLP and OECD guideline implementation.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- No further information available.
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- not specified
- Remarks:
- albino rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Age at study initiation: young adult rats
- Weight at study initiation: 200-300 grams
- Fasting period before study: yes, fasted for twenty-four hours
- Housing: common cage
- Diet: ad libitum
- Water: ad libitum - Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Doses:
- 250 mg/kg
500 mg/kg
630 mg/kg
800 mg/kg
1000 mg/kg
2000 mg/kg - No. of animals per sex per dose:
- 5 male and 5 female were used for each dose level.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: no - Preliminary study:
- not reported
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 725 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 605 - <= 875
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 775 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 670 - <= 895
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- ca. 250 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- ca. 500 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD100
- Effect level:
- ca. 1 000 mg/kg bw
- Mortality:
- Please see table 1 in section "any other information on results incl. tables".
- Clinical signs:
- Please refer to section "any other information on results incl. tables".
- Body weight:
- not examined
- Gross pathology:
- not performed
- Other findings:
- none reported
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 value of the test item is 725 mg/kg (male albino rats). Therefore, the test item will be classified as acute toxic; category 4; oral, H302.
- Executive summary:
In an acute oral toxicity, groups of fasted male and female albino rats were given a single oral dose of sodium dicyanoamide in propylene glycol at doses of 250, 500, 630, 800, 1000 and 2000 mg/kg bw. The animals were observed daily for a two-week period.
The oral LD50 in males was 725 mg/kg bw (95% CL: 605 -875 mg/kg bw) and 775.0 mg/kg bw in females (95% CL: 670.0 - 895.0 mg/kg bw).
All animals died at a dose of 1000 mg/kg bw and higher. At lower doses, symptoms like unkempt coats, lethargy, convulsions and haemorrhage were observed.
The LD50 value of the test item is 725 mg/kg bw in male albino rats, therefore the test item will be classified as acute toxic; category 4; oral, H302 according to GHS/CLP classification criteria.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Handbook data; original report not available
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 000 mg/kg bw
- Sex:
- not specified
- Dose descriptor:
- other: LD50 intraperitoneal
- Effect level:
- ca. 610 mg/kg bw
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The oral LD50 in mice is about 1000 mg/kg and the intraperitoneal LD50 610 mg/kg.
- Executive summary:
According to a publication which has been cited in the handbook "Patty’s Toxicology, Sixth Edition. Volume 2", the oral LD50 of sodium dicyanoamide in mice is about 1000 mg/kg and the intraperitoneal LD50 610 mg/kg.
The original report as cited in the handbook was not avaible and thus, details on the experimental procedure are lacking.
Referenceopen allclose all
Table 1: Experimental data:
Dose level mg/ kg bw |
No. of male rats |
Survivors |
Deaths |
Day of deaths |
250 |
5 |
5 |
0 |
- |
500 |
5 |
4 |
1 |
1 |
630 |
5 |
4 |
1 |
1 |
800 |
5 |
2 |
3 |
1 |
1000 |
5 |
0 |
5 |
1 |
2000 |
5 |
0 |
5 |
1 |
Dose level mg/ kg bw |
No. of female rats |
Survivors |
Deaths |
Day of deaths |
250 |
5 |
5 |
0 |
- |
500 |
5 |
5 |
0 |
- |
630 |
5 |
4 |
1 |
2 |
800 |
5 |
3 |
2 |
1 |
1000 |
5 |
0 |
5 |
1 |
2000 |
5 |
0 |
5 |
1 |
Observations:
Males: At 250 mg/kg, the animals were languid with nasal haemorrhage and ruffled, unkempt coats. The animals dosed at 500, 630, 800 and 1000 mg/kg were lethargic with very ruffled, unkempt coats. Within one hour, all animals were crouched in a fetal position. At this time, ocular and nasal haemorrhage were first evident. Convulsions began about 2-2.5 hours after intubation. Survivors remained unkempt throughout the observation period. Symptoms of toxicity at 2000 mg/kg were the same as at 1000 mg/kg except for their severity. All animals succumbed within 2 hours.
Females: Nasal haemorrhage, sluggish locomotion and ruffled, unkempt coats were noted at 250 mg/kg. At dosage level of 500 mg/kg, 630 mg/kg and 800 mg/kg, the animals were lethargic with ruffled, unkempt coats. Spasmodic movements were noted. Within an hour, all animals were in a fetal position. Lacrimation, ocular and nasal haemorrhage were noted. Convulsions began approximately two hours after dosing. The animals dosed at 1000 mg/kg and 2000 mg/kg showed the same toxicity as at 800 mg/kg. All animals died within 2 -4 hours after incubation.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 725 mg/kg bw
Additional information
Justification for classification or non-classification
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