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EC number: 218-880-1 | CAS number: 2273-43-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Butylhydroxyoxostannane
- EC Number:
- 218-880-1
- EC Name:
- Butylhydroxyoxostannane
- Cas Number:
- 2273-43-0
- Molecular formula:
- C4H10O2Sn
- IUPAC Name:
- butyl(oxo)stannanol
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: white powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 to 295 g
- Fasting period before study: nineteen hours prior to test material administration
- Housing: collectively housed
- Diet: ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 30 % (w/v) solution in tap water - Doses:
- 10.0 and 20.0 g/kg
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Observations for mortality and overt signs of effect were made at 0-2 hours, and at 4-6 hours following dosing and daily thereafter for fourteen days.
- Body weights were recorded initially and terminally.
- A gross necropsy was performed on spontaneous deaths.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 20 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One animal at 20.0 g/kg died during this study.
- Clinical signs:
- other: Common in-life signs of effect noted during the fourteen day study included: ataxia, coarse and fine tremors, red nasal and red oral discharges, urinary staining of the abdomen, piloerection, motor activity decrease, animal thinness, abdominal griping, ir
- Gross pathology:
- Necropsy observations for the animal that died during the study were: clear oral discharge; red nasal discharge; urinary staining of the abdomen; stomach and intestines: distended with gas; liver: mottled; thoracic cavity contains red congealed substance.
Any other information on results incl. tables
Table 1: Summary of In-life Observations
Dose level (g/kg) |
Observation |
Incidence (number observed) |
|||||||
Hours |
Days |
||||||||
0-2 |
4-6 |
1 |
2 |
3 |
4 |
7 |
14 |
||
10 |
Surviving animals |
10 |
10 |
10 |
10 |
10 |
10 |
10 |
10 |
Red nasal discharge |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Chromodacryorrhea |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
|
Piloerection |
6 |
3 |
4 |
2 |
0 |
0 |
2 |
0 |
|
Motor activity decrease |
9 |
8 |
8 |
9 |
0 |
0 |
1 |
0 |
|
Animal thinning |
0 |
0 |
3 |
3 |
0 |
0 |
0 |
0 |
|
NOA |
0 |
2 |
1 |
1 |
10 |
10 |
7 |
9 |
|
20 |
Surviving animals |
10 |
10 |
10 |
10 |
10 |
10 |
9 |
9 |
Ataxia |
0 |
0 |
1 |
0 |
0 |
1 |
0 |
0 |
|
Fine tremors |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Coarse tremors |
0 |
0 |
3 |
0 |
0 |
1 |
0 |
0 |
|
Red nasal discharge |
0 |
4 |
1 |
1 |
2 |
0 |
1 |
0 |
|
Clear nasal discharge |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
|
Laboured breathing |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Respiratory rate decrease |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
|
Red oral discharge |
0 |
1 |
0 |
1 |
2 |
0 |
0 |
0 |
|
Urinary staining |
0 |
3 |
0 |
0 |
0 |
1 |
0 |
0 |
|
Faecal staining |
0 |
2 |
2 |
0 |
0 |
0 |
0 |
0 |
|
Red staining on abdomen |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
|
Soft stool |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
White stool |
0 |
0 |
6 |
1 |
0 |
0 |
0 |
0 |
|
Pale stool |
0 |
0 |
0 |
0 |
2 |
1 |
0 |
0 |
|
Piloerection |
3 |
5 |
5 |
0 |
2 |
3 |
1 |
1 |
|
Motor activity decrease |
10 |
10 |
8 |
3 |
3 |
2 |
3 |
2 |
|
Motor activity increase |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
|
Animal thinning |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
|
Irritability |
0 |
0 |
1 |
0 |
2 |
0 |
1 |
0 |
|
Abdominal griping |
0 |
0 |
0 |
0 |
2 |
2 |
0 |
0 |
|
Ears reddened |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
|
NOA |
0 |
0 |
1 |
7 |
7 |
7 |
4 |
5 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified in accordance with EU Criteria
- Conclusions:
- Under the conditions of this study the acute oral LD50 of the test material was determined to be greater than 20 g/kg, the highest dose tested.
- Executive summary:
The acute oral toxicity of the test material was investigated in a study similar to OECD 401.
During the study, ten animals (5/sex) were dosed at 10.0 and 20.0 g/kg. A rangefinding study was performed to arrive at the appropriate dose levels. The test material was administered by oral intubation as a 30 % w/v solution in tap water. Observations for mortality and overt signs of effect were made at 0-2 hours, and at 4-6 hours following dosing and daily thereafter for fourteen days. Body weights were recorded initially and terminally and a gross necropsy was performed on spontaneous deaths.
Common in-life signs of effect noted during the fourteen day study included: ataxia, coarse and fine tremors, red nasal and red oral discharges, urinary staining of the abdomen, piloerection, motor activity decrease, animal thinness, abdominal griping, irritability, and white stool. Signs of effect persisted throughout the study. A loss of weight or a failure to exhibit normal weight gain was noted in 4 of 10 surviving animals at 10.0 g/kg and 1 of 9 surviving animals at 20.0 g/kg.
One animal at 20.0 g/kg died during this study. Necropsy observations for this animal were: clear oral discharge; red nasal discharge; urinary staining of the abdomen; stomach and intestines: distended with gas; liver: mottled; thoracic cavity contains red congealed substance.
Under the conditions of this study the acute oral LD50 of the test material was determined to be greater than 20 g/kg, the highest dose tested.
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