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Diss Factsheets
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EC number: 202-225-1 | CAS number: 93-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to acute tox. method. Non-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- other: BASF Test
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 3,4-dimethoxyphenylacetonitrile
- EC Number:
- 202-225-1
- EC Name:
- 3,4-dimethoxyphenylacetonitrile
- Cas Number:
- 93-17-4
- Molecular formula:
- C10H11NO2
- IUPAC Name:
- 3,4-dimethoxyphenylacetonitrile
- Test material form:
- solid
- Details on test material:
- Veratrylcyanid, PSN 78/834; no data on purity given in the report.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - diet: Herilan MRH-Haltung; H. Eggersmann KG
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 0.5 % aqueous CMC
- Doses:
- 50, 200 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - way of application: intraperitoneal
- form of application: suspension
- formulation in: 0.5% aqueous carboxymethyl cellulose
- fasting before application: 15 - 20 h
- observation period: 14 days
- max. volume applied: 10 mL/kg bw.
- range of concentration: 2.0-0.5 % (g/v)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 50 - < 200 mg/kg bw
- Mortality:
- Mortality in male rats after 1 hour/1 day/2 days/7 days/14 days:
- 200 mg/kg bw dose level: 5/5/5/5/5
- 50 mg/kg bw dose level: 0/0/0/0/0
Mortality in female rats after 1 hour/1 day/2 days/7 days/14 days:
- 200 mg/kg bw dose level: 5/5/5/5/5
- 50 mg/kg bw dose level: 1/1/1/1/1 - Clinical signs:
- - 200 mg/kg bw dose level: dyspnoe, apathy, abnormal position, staggering, atonia, no reflex on pain, convulsion, exsiccosis, poor general state.
- 50 mg/kg bw dose level: dyspnoe, apathy, abnormal position, staggering, tremor, convulsion, exsiccosis, poor general state. - Body weight:
- Mean body weight [g] in male rats before application/2-4 days after appl./7 days after appl./13 days after appl.
- 464 mg/kg bw dose level:----
- 316 mg/kg bw dose level: 24/27.6/30.6/34.2
Mean body weight [g] in female rats before application/2-4 days after appl./7 days after appl./13 days after appl.
- 464 mg/kg bw dose level:----
- 316 mg/kg bw dose level: 24/25/27.5/28.3
Any other information on results incl. tables
Groups of 5 male and 5 female NMRI mice were given a single intraperitoneal injection of the test substance at dose levels of 50 and 200 mg/kg bw. For application, the test substance was suspended in a 0.5% aqueous preparation of carboxymethylcellulose; the suspensions were injected at 10 ml/kg bw. After dosing, the animals were observed for 14 days. One low dose female and all high dose animals died within one hour after dosing. Signs of toxicity were observed at both dose levels and included dyspnea, apathy, anomal position, staggering, atony, loss of pain reflex, narcotic-like state, tremor, spastic gait, rolling fitm, tonic convulsion, clonic convulsion, exsiccosis and poor general state. Body weight gains of the survivors were within the expected range. Post-mortem examination of the decedents and survivors revealed no pathological findings
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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