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EC number: 235-979-5 | CAS number: 13078-36-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The target substance (DTPA 3Na) is the trisodium salt of the source substance (DTPA). The purity/impurity profile for the source substance (supplied by Fluka Chemical Co.) is not reported in the source publication (Arch. Environ. Contam. Toxicol. 31, 433-443 (1996)), but since the target substance is > 99.9% pure and contains no detectable impurities, the extrapolation of short-term aquatic toxicity properties from the source material to the target material is considered valid as a ‘worst case' scenario. The source material short-term Daphnia toxicity test was conducted according to OECD guideline 202 and was considered reliable with restrictions (Category 2).
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 1984
- Deviations:
- yes
- Remarks:
- LC50s rather than EC50s used as the endpoint
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Supplied by Fluka Chemical Co.
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other: Daphnia carinata
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- Not specified
- Test temperature:
- 20 +/- 1 degrees Centigrade
- pH:
- 6.8-7.0
- Dissolved oxygen:
- > 70% (6.5 mg/l)
- Salinity:
- Not applicable
- Conductivity:
- Not specified
- Nominal and measured concentrations:
- Nominal concentration: 0, 25, 50, 100, 200, 4000, 800 mg/L DTPA.
- Details on test conditions:
- Keating's MS animal medium (Keating 1986) used as the test system
- Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 332.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 245 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Geometric mean of the lowest and highest concentrations giving 0 or 100% mortality
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- 24h LC50 was 342.9 (168.5-678.6 mg/L 95% confidence limits) and 48 h LC50 245.0 (200-400 95% confidence limits)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 48h LD50 of the test substance to Daphnia Carinata is 245 mg/L
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The target substance (DTPA 3Na) is the trisodiun salt of the source substance Diethylenetriaminepentaacetic acid (DTPA), and is therefore structurally similar. The two substances have high water solubility and would be dissociated in the aquatic environment. It is manufactured by the addition of an appropriate molar ratio of sodium hydroxide to the parent acid to give a neutral solution. The target substance is pH 7.5 +/- 0.5 in solution which is comparable to the test conditions used for the short-term Daphnia toxicity test with the acid (pH 6.8-7.0). The common organic acid moiety has a chelating mode of action and would be expected to exert long-term, non-specific adverse, systemic effects by the sequestration of essential metal ions, rather than acute toxicity. The extrapolation of short-term aquatic toxicity potential from the source to the target substance is therefore considered valid.
- Reason / purpose for cross-reference:
- read-across source
- Specific details on test material used for the study:
- >99% purity
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 284 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Conclusions:
- The EC50 to Daphmia carinata is predicted to be 284 mg/L.
- Executive summary:
Using a read-across approach from a study conducted on the structural analogue DTPA acid, the EC50 of DTPA trisodium salt to Daphnia carinata is predicted to be 284 mg/L (on stoichiometric basis). The two substances are structurally very similar, particularly when ionised in the aqueous environment. Moreover, the Daphnia carinata acute toxicity study of DTPA acid was undertaken at a pH (6.8-7.0) equivalent to the netural pH of the test substance.
Referenceopen allclose all
Description of key information
Using a read-across approach from a study conducted on the structural analogue DTPA acid, the EC50 of DTPA trisodium salt to Daphnia carinata is predicted to be 284 mg/L (on stoichiometric basis). The two substances are structurally very similar, particularly when ionised in the aqueous environment. Moreover, the Daphnia carinata acute toxicity study of DTPA acid was undertaken at a pH (6.8-7.0) comperable to the netural pH of the test substance (7.5 +/- 0.5).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 284 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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