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EC number: 690-928-8 | CAS number: 39992-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03/2017 - 03/2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Batch: 703709
Purity: 100 %
CoA: 2017-02-15 - Analytical monitoring:
- yes
- Details on sampling:
- Analytical data are required by the guidelines for verification of test item concentrations as well as
the stability of the test item over the entire test period. Analytical samples were taken from all test
item concentrations and control at test start and after 48 hours from aged solutions. For each
sampling also a retain sample was taken.
All samples were stored deep frozen until they were transferred to the analytical laboratory. - Vehicle:
- no
- Details on test solutions:
- The following nominal concentrations were tested: 6.25, 12.5, 25.0, 50.0 and 100 mg/L and control.
The necessary amount of test item for preparing the stock solution S1 was weighed on a weighing
scoop and transferred to a volumetric flask. Test medium (see Appendix B) was added up to the
bench mark and the solution was homogenised by shaking and treated with 120 minutes of ultrasonication.
Afterwards the solution was clear and transparent and foam was visible. Lower test
solutions were prepared by dilution of the appropriate solution with test medium. - Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Hardness:
- 13°dH (232 mg/L CaCO3);
- Test temperature:
- 19.1 – 22.0 °C
- pH:
- 7.40 – 8.02
- Dissolved oxygen:
- ≥ 8.0 mg/L
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate; 1.00 mg/L, 2.00 mg/L
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- According to the results of the test, the EC50 (48 h) for immobilisation was determined to be > 100 mg/L (nominal). The corresponding NOEC (48 h) was 100 mg/L (nominal).
- Executive summary:
Study Objective: The objectives of this study were to determine the immobilisation effect of the test item on the water flea Daphnia magna under worst-case exposure conditions, the no observed effect concentration (NOEC) and the effect median concentration (EC50).
Material and methods: Test item: IPDI-Uron, batch number: 703709, purity analysed: 100 % w/w.
Test species: Daphnia magna Straus, Clone V, max. 24 hours old.
Test design: Static dose-response test with twenty organisms per test concentration (4 replicates of 5 animals each) were used. The duration of the test was 48 hours.
Endpoints: Endpoints reported are the EC50 and the NOEC after 24 and 48 hours, where possible.
Test rates: A static main test with nominal concentrations of 100, 50.0, 25.0, 12.5, 6.25 mg/L and control was performed.
Test conditions: Temperature, pH-value and oxygen concentration of the test solutions measured after 0, 24 and 48 hours are reported. Hardness of the test water was measured on the day of application.
Samples analysed: Analytical samples taken at 0 hours (initial value) and 48 hours aged test solutions were analysed from control and 100 mg/L.
Statistics: The values for EC50 could not be determined since no immobilisation above the allowed control immobilisation occurred during the test. The NOEC was established based on the highest concentration at which the immobilisation is not higher than the allowed control immobilisation (≤ 10 % immobilisation).
Findings:
Validity criteria: Control immobilisation: The percentage of immobilisation should be ≤ 10 % In this study the control immobilisation was 0 %.
Oxygen concentration: The dissolved oxygen concentration at the end of the test should be ≥ 3 mg/L in all test units. In this test, the dissolved oxygen concentration at the end of the test was ≥ 8.0 mg/L.
Test conditions: The total hardness (as CaCO3) of the untreated control was determined to be 13°dH (232 mg/L CaCO3);
the mean pH-value of the untreated control was determined to be 7.54 ± 0.14 (Std. Dev.);
the mean temperature of the control and all test item concentrations was measured to be 20.0 ± 1.0 °C (Std. Dev.);
the mean oxygen concentration was determined to be 9.0 ± 0.3 mg/L (Std. Dev.).
Analytical Results: The measured content of IPDI-Uron was 111 % of nominal in the fresh sample. In the aged sample the measured content was 107 % of nominal.
Therefore toxicological endpoints were evaluated using the nominal concentrations of the test item.
Statistical Results: EC50 and NOEC-values of daphnids exposed to the test item evaluated using nominal concentrations
Test item [mg/L] (nominal) 24 h 48 h NOEC 100 100 EC50 > 100 > 100 95 % confidence limit of EC50 - - - not applicalbe
Conclusions: According to the results of the test, the EC50 (48 h) was determined to be > 100 mg/L (nominal). The corresponding NOEC (48 h) was 100 mg/L (nominal).
Reference
Description of key information
According to the results of the test, the EC50 (48 h) for immobilisation was determined to be > 100 mg/L (nominal). The corresponding NOEC (48 h) was 100 mg/L (nominal).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Additional information
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