Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-636-9 | CAS number: 108-99-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: textbook
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data obtained from a reliable handbook of physico-chemical values.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Heterocyclic and Miscellaneous Nitrogen Compounds
- Author:
- Trochimowicz HL
- Year:
- 1 994
- Bibliographic source:
- in Patty's Industrial Hygiene and Toxicology, 4th Ed. (GD Clayton and FE Clayton, eds), New York, John Wiley and Sons
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Unknown method, as provided in a reputable textbook. We defer to the editors of the textbook to ensure that valid methods were used to generate this data. Handling experience with this value has not resulted in the questioning of its accuracy.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-methylpyridine
- EC Number:
- 203-636-9
- EC Name:
- 3-methylpyridine
- Cas Number:
- 108-99-6
- Molecular formula:
- C6H7N
- IUPAC Name:
- 3-methylpyridine
Constituent 1
Test animals / tissue source
- Species:
- other: likely rabbit, but no data in this textbook
Results and discussion
In vivo
Results
- Irritation parameter:
- other: qualitative assessment
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 8
- Max. score:
- 10
- Reversibility:
- not reversible
- Remarks on result:
- other: moderately to severely irritating
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- 3-Methylpyridine was evaluated to be moderately to severely irritating to the eye, according to a reputable textbook.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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