Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-340-2 | CAS number: 119-64-2
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Metabolism and nephrotoxicity of tetralin in male Fischer 344 rats
- Author:
- Servé MP, Llewelyn BM, Yu KO, McDonald GM, Olson CT and Hobson DW
- Year:
- 1 989
- Bibliographic source:
- J. Toxicol. Environ. Health 26, 267-275
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
- Type of study / information:
- Type: other: Nephrotoxicity and Metabolism
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2,3,4-tetrahydronaphthalene
- EC Number:
- 204-340-2
- EC Name:
- 1,2,3,4-tetrahydronaphthalene
- Cas Number:
- 119-64-2
- Molecular formula:
- C10H12
- IUPAC Name:
- 1,2,3,4-tetrahydronaphthalene
- Details on test material:
- 1,2,3,4-Tetrahydronaphthalene from Aldrich Chemical Co., Milwaukee; metabolite standards from same source or synthesized according to procedures reported. Purities not reported.
Constituent 1
Results and discussion
Any other information on results incl. tables
RENAL DAMAGE:
- Exposed and control female rats did not display any renal damage.
- Male exposed rats exhibited increased cytoplasmic hyaline droplets in proximal convoluted tubular epothelial cells, which were
indicative for toxic injury. Additionally, foci of cellular degeneration were present within proximal convoluted tubules. Intratubular
cellular casts, overt glomerular changes or significant inflammation was not seen.
METABOLITES identified (mean percentages in all 36 samples):
1,2,3,4-tetrahydro-1-naphthol, CAS No. 529-33-9 (29 %)
1,2,3,4-tetrahydro-2-naphthol, CAS No. 530-91-6 (7 %)
1,2,3,4-tetrahydro-1-oxo-2-naphthol (33 %)
1,2,3,4-tetrahydro-1-oxo-4-naphthol (25 %)
1,2,3,4-tetrahydronaphthalene-1,4-diol (1 %)
1,2,3,4-tetrahydronaphthalene-1,2-diol (traces)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
