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Diss Factsheets
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EC number: 259-587-9 | CAS number: 55310-46-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data on skin sensitizing properties of isolated (anhydrous) sodium dibenzyldithiocarbamate are available. However, the substance is solely manufactured and marketed by the registrant as a saturated aqueous solution (ca. 17% w/w) and it is not expected that exposure to pure substance is possible. Therefore for the risk assessment it is considered to be acceptable and in fact more relevant to use skin sensitization data on the substance as manufactured.
The ability of sodium dibenzyldithiocarbamate (SBEC) in 16.9% aqueous solution to induce skin sensitization was studied in a local lymph node assay (LLNA) according to OECD guideline 429 and GLP (Notox B.V., 2001). The 25 μl of the test substance as 25%, 50% and 100% in DMF (dimethylformamide) was applied to the dorsal surface of each mouse ear on three consecutive days. The stimulation index (SI) values calculated for each concentration were 0.77, 0.47 and 0.53, respectively, indicating that the substance as manufactured (as ca. 17% aqueous solution) does not possess skin sensitizing properties. It should be noted that no conclusion on the skin sensitizing properties of the pure (anhydrous) substance can be made based on these data.
Migrated from Short description of key information:
No data are available on skin sensitizing properties of isolated (anhydrous) sodium dibenzyldithiocarbamate. However, as the substance is manufactured and marketed by the registrant solely as a saturated (ca. 17%) aqueous solution, an exposure to pure substance is not expected to be possible. Therefore for the risk assessment purposes it is considered to be acceptable and in fact more relevant to use skin sensitization data on the substance as manufactured.
Based on the results of GLP-compliant OECD 429 Guideline study, the substance in its marketed form (as ca. 17% aqueous solution) is considered to be not sensitizing (stimulation index of 0.53 in LLNA test).
Justification for classification or non-classification
Based on the SI value of 0.53 obtained in the GLP-compliant LLNA assay for sodium dibenzyldithiocarbamate in its marketed form (as 16.9% aqueous solution), the substance should not be classified as skin sensitizer according to the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
It should be stated that these classification and labeling are not applicable for the isolated substance; however, as the substance is solely manufactured and marketed by the registrant as a saturated (ca. 17%) aqueous solution, the classification as reported above is considered to be acceptable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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