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Diss Factsheets
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EC number: 270-735-1 | CAS number: 68477-50-9 A complex combination of hydrocarbons obtained from the distillation of polymerized steam-cracked petroleum distillate. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C5 through C12.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, guideline study available as unpublished report, no restrictions, fully adequate for assessment. NOTE data cannot be used for classification.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- other: Acute limit test
- Limit test:
- yes
Test material
- Details on test material:
- - Name of test material (as cited in study report): MRD-91-935
- Physical state: pale yellow liquid
- Analytical purity: assumed 100%
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CDBr (Sprague Dawley)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Kingston Facility, Stone Ridge, New York, USA.
- Age at study initiation: Males approx 8 weeks , females approx 10 weeks
- Weight at study initiation: Males 196.14-210.00 g, females 202.82-213.89 g
- Housing: individually
- Diet: Purina Certified Rodent Chow ad libitum (except overnight prior to dosing).
- Water: Mains water ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature: 68-76°F
- Humidity: 40-70%
- Air changes (per hr): Not reported
- Photoperiod: 12hrs dark / 12hrs light
IN-LIFE DATES: From: 8 July 1991 To: 22 July 1991
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- DOSE VOLUME: 7.4305 mL/kg
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Examined for viability twice daily weekdays and once per day at weekends. Bodyweights recorded prior to dosing, at time of dosing (day 0) and on days 7 and 14.
- Necropsy of survivors performed: yes - Statistics:
- Means and SDs of bodyweights were calculated.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 5 000 mg/kg bw
- Remarks on result:
- other: 3/5 males and 4/5 females died following a limit dose of 5000 mg/kg.
- Mortality:
- Three males and three females found dead on day 0 and a further female found dead on day 2.
- Clinical signs:
- Majority of abnormal clinical signs were seen in first 6 hours after dosing and included hypoactivity, hypothermia, red anal discharge, wet/dry rales and various ocular and oral discharges. The two surviving males displayed no abnormalities from day 3 onwards. The surviving female had rales, decreased food consumption, small amount of stool and emaciation sporadically until termination.
- Body weight:
- Two surviving males increased in bodyweight but the surviving female lost weight over the study.
- Gross pathology:
- In decedents, abnormal contents, vascularisation and reddened mucosa of the stomach and small and large intestines, plus staining of the fur was present. No abnormalities were seen in the two surviving males. The following were seen in the surviving female: a hole in the diaphragm, emaciation, uterine distension and alopecia.
Applicant's summary and conclusion
- Interpretation of results:
- other: unable to classify, dose used higher than LD 50
- Conclusions:
- The acute oral LD50 to male and female was less than 5000 mg/kg bodyweight.
- Executive summary:
The acute oral LD50 to male and female was less than 5000 mg/kg bodyweight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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