Naphthalene-2-sulphonyl chloride

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two toxicity to micro-organism studies as-
2. and 3.

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: 2. Pseudomonas fluorescens and 3. Pseudomonas putida

Test type:

not specified

Water media type:

freshwater

Total exposure duration:

24 h

Reference substance (positive control):

not specified

Duration:

24 h

Dose descriptor:

EC0

Effect conc.:

500 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Remarks on result:

other: 2. No effect were observed on multiplication of bacterial cells.

Duration:

17 h

Dose descriptor:

EC10

Effect conc.:

140 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Remarks on result:

other: 3.

Duration:

17 h

Dose descriptor:

EC50

Effect conc.:

190 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Remarks on result:

other: 3.

Duration:

17 h

Dose descriptor:

other: EC90

Effect conc.:

240 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Remarks on result:

other: 3.

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 190 mg/l, respectively.

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on micro-organisms.The studies are as mentioned below:

Short term toxicity to Pseudomonas fluorescens study was carried out for 24 hr.The study was based on the effects of the test chemical on Pseudomonas fluorescens. Pseudomonas fluorescens was used as a test organism. On the basis of the effect of test chemical on growth rate, i.e, multiplication of the test organism Pseudomonas fluorescens, the 24 h EC0 value was determined to be 500 mg/l.

Another short term toxicity to Pseudomonas putida study was carried out for 17 hr.The study was based on the effects of the test chemical on Pseudomonas putida. Pseudomonas putida was used as a test organism. On the basis of the effect of test chemical on growth rate, i.e, cell multiplication of the test organism Pseudomonas putida, the 17 h EC10, EC50 and EC90 value was determined to be 140, 190 and 240 mg/l, respectively.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 190 mg/l, respectively.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 190 mg/l, respectively.

Key value for chemical safety assessment

EC50 for microorganisms:

190 mg/L

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on micro-organisms. The studies are as mentioned below:

 

Short term toxicity to Pseudomonas fluorescens study was carried out for 24 hr. The study was based on the effects of the test chemical on Pseudomonas fluorescens. Pseudomonas fluorescens was used as a test organism. On the basis of the effect of test chemical on growth rate, i.e, multiplication of the test organism Pseudomonas fluorescens, the 24 h EC0 value was determined to be 500 mg/l.

 

Another short term toxicity to Pseudomonas putida study was carried out for 17 hr. The study was based on the effects of the test chemical on Pseudomonas putida. Pseudomonas putida was used as a test organism. On the basis of the effect of test chemical on growth rate, i.e, cell multiplication of the test organism Pseudomonas putida, the 17 h EC10, EC50 and EC90 value was determined to be 140, 190 and 240 mg/l, respectively.

 

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the EC50 value was determined to be 190 mg/l, respectively.