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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin irritation: 1 key study / 1 supporting study available: not irritating
Eye irritation: 1 key study / 1 supporting study available: irritating/not irritating

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

There are one key study and one supporting study available on the skin irritancy potential. 2,4 -Xylidine was tested for its skin irritant properties in 3 New Zealand white rabbits. The study was performed according to OECD Guideline 404 without any deviations. Effects on skin (mean erythema score 0.2 and mean edema score 0) were observed in the animals 24-72 hours after application. These signs were fully reversible within the 72 hours observation period.

There are one key and one supporting study available on the eye irritancy potential. 2,4 -Xylidine was tested for its eye irritant properties in 3 New Zealand White rabbits. The study was performed according to OECD Guideline 405. Effects on cornea, conjunctivae and iris were observed in the animals after application. These signs were fully reversible within 7 days.

Effects on eye irritation: irritating

Justification for classification or non-classification

With reference the reported scores and the full reversibility of the observed effects to the skin 2,4 -Xylidine has not to be classified as irritant to the skin according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).

With reference the reported scores and the full reversibility of the observed effects to the eyes 2,4 -Xylidine has to be classified as irritant to the eye (Xi (irritant), R36 - irritating to the eyes; Cat. 2, H319 - causes serious eye irritation) according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).