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EC number: 807-113-1 | CAS number: 3709-71-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Henry's Law constant
Administrative data
- Endpoint:
- Henry's law constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 2, 2014 - October 9, 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP study with acceptable method.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The Henry's Law constant of HFP Kinetic Dimer was determined by the ratio of gas-phase concentration over aqueous phase concentration for a given test system vessel at equilibrium conditions and at ambient temperature and pressure.
- GLP compliance:
- yes
Test material
- Reference substance name:
- HFP kinetic dimer
- IUPAC Name:
- HFP kinetic dimer
- Details on test material:
- - Name of test material (as cited in study report): Hexafluoropropylene (HFP) Kinetic Dimer
- Substance type: Single component substance
- Physical state: Clear, colorless liquid
Constituent 1
Results and discussion
Henry's Law constant H
- Key result
- H:
- 5 690
- Temp.:
- 22 °C
- Atm. press.:
- 760 mm Hg
- Remarks on result:
- other: %RSD = 18. Average Log HLC = 3.8, %RSD = 2.5%.
Any other information on results incl. tables
Table 1: Summary of Henry’s Law Constant (HLC) forHFP Kinetic Dimer
Ratio (Headspace: Aqueous) |
Replicate |
Time point 1 (Four days) |
Time point 2 (Five days) |
Time point 3 (Six days) |
70 % Headspace |
1 |
7120 |
6800 |
4860 |
2 |
4960 |
6380 |
3460 |
|
Average |
6040 |
6590 |
4160 |
|
%RPD |
36(1) |
6.4 |
34(1) |
|
50 % Headspace |
1 |
5710 |
6370 |
6250 |
2 |
6760 |
7940 |
3770 |
|
Average |
6240 |
7150 |
5010 |
|
%RPD |
17 |
22 |
49(1) |
|
30 % Headspace |
1 |
5160 |
6240 |
4650 |
2 |
5680 |
6480 |
5920 |
|
Average |
5420 |
6360 |
5290 |
|
%RPD |
9.7 |
3.8 |
24 |
|
Intra-Time Point Average % RSD |
5900 15 |
6700 9.5 |
4820 23 |
|
Overall Average %RSD |
5690 18 |
(1) Calculated values of HLC did not meet the targeted precision of <25% for intra-vial replicates.
Table 2: Summary of Log (HLC) forHFP Kinetic Dimer
Ratio (Headspace: Aqueous) |
Replicate |
Time point 1 (Four days) |
Time point 2 (Five days) |
Time point 3 (Six days) |
70 % Headspace |
1 |
3.9 |
3.8 |
3.7 |
2 |
3.7 |
3.8 |
3.5 |
|
Average |
3.8 |
3.8 |
3.6 |
|
%RPD |
4.1 |
0.73 |
4.1 |
|
50 % Headspace |
1 |
3.8 |
3.8 |
3.8 |
2 |
3.8 |
3.8 |
3.6 |
|
Average |
3.8 |
3.8 |
3.7 |
|
%RPD |
1.9 |
2.5 |
5.9 |
|
30 % Headspace |
1 |
3.7 |
3.8 |
3.7 |
2 |
3.8 |
3.8 |
3.8 |
|
Average |
3.7 |
3.8 |
3.7 |
|
%RPD |
1.1 |
0.43 |
2.8 |
|
Intra-Day Average % RSD |
3.8 1.7 |
3.8 1.0 |
3.7 2.8 |
|
Overall Average %RSD |
3.8 2.5 |
Applicant's summary and conclusion
- Conclusions:
- The Henry's Law constant (HLC) for HFP Kinetic Dimer was determined based on measured concentrations in the gas-phase and aqueous-phase. Under an average study temperature of 22°C, the average HLC was 5690, the average log HLC was 3.8.
- Executive summary:
The Henry's Law constant of HFP Kinetic Dimer was determined by the ratio of gas-phase concentration over aqueous-phase concentration.
Duplicate test vessels were filled with water and dosed with HFP Kinetic Dimer gas at three headspace:water ratios (70%, 50% and 30%). The vials were incubated for 4, 5, and 6 days at ambient temperature. Both the headspace and the water phase for each vial were sampled and analyzed in duplicates using gas chromatography/mass spectrometry (GC/MS). The average measured gas phase and water phase concentrations were used to calculate Henry's Law constant for HFP Kinetic Dimer for each test vessel. Under the conditions of this study (average temperature of 22°C), overall average HLC for HFP Kinetic Dimer is 5690 (%RSD = 18), the overall average log HLC was 3.8 (% RSD= 2.5). The dimensionless HLC can be converted to 1.40E+07 Pa·m³/mol (138 atm·m³/mole).
This study was conducted under GLP compliance with accepted method. However, there were seveal samples that had high %RPD. Therefore, it is considered reliable with restrictions.
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