1,5,10-trimethylcyclododeca-1,5,9-triene, epoxidised

Endpoint summary

Description of key information

The registered substance is hydrolytically stable at pH>5 and is not readily biodegradable. In addition, the biodegradation result obtained after 60 days does not allow us to conclude that the registered substance is not persistent in the environment even if, after a long period of time, the substance would be expected to ultimately biodegrade.

Based on a QSAR approach, the estimated BCF values of the registered substance well all comprised between 407 and 4219 L/kg, calculated using the experimental log Kow value at 5.05. Based on these available data, the registered substance seems to be bioaccumulable (log Kow > 4.5 and BCF > 2000 L/kg) but not very bioaccumulable (BCF < 5000 L/kg) according to PBT criteria. However, as the log Kow of the substance is high it may be expected to be found mostly in the adsorbed form and therefore more likely to be ingested than absorbed through the gills. At pHs found in the stomach of fish (generally comprised between 2 and 4), hydrolysis of the registered substance is expected to occur before biotransformation in the liver. In acidic conditions and up to pH 5, the registered substance is known to be unstable and will hydrolyze to give a poly-hydroxylated degradation product. The BCF value of this hydrolysis product / metabolite at acid pH (the diol form) is calculated to be low, at 12.9 L/kg. Therefore, we can conclude that the registered substance is not bioaccumulable.

Finally, the adsorption coefficient of the registered substance has been evaluated to be in the range of 150 to 3940, corresponding to a log Koc comprised between 2.18 and 3.60. This result indicates that the registered substance has a medium to slightly mobility in soils (according to P.J. McCall et al., 1981).