Registration Dossier
Registration Dossier
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EC number: 909-034-9 | CAS number: -
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Selective degeneration in the rat olfactory bulb following exposure to different odours
- Author:
- Pinching AJ and Doeving KB
- Year:
- 1 974
- Bibliographic source:
- Brain Res. 82, 195-204
Materials and methods
- Type of study / information:
- Effect on olfactory bulb
- Principles of method if other than guideline:
- Degeneration in rat olfactory bulb following exposure to cyclododecanone
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclododecanone
- EC Number:
- 212-595-6
- EC Name:
- Cyclododecanone
- Cas Number:
- 830-13-7
- Molecular formula:
- C12H22O
- IUPAC Name:
- Cyclododecanone
- Details on test material:
- no data
Constituent 1
Results and discussion
Any other information on results incl. tables
Principal effects were darkening and shrinkage of the cell bodies (both cytoplasm and nucleus).
For cyclododecanone a more extensive degeneration in the posterior than in the anterior region was found.
For each of the 44 different odors investigated in this study, a specific pattern of mitral cell degeneration was observed in the
olfactory bulb; the pattern and extent of this 'selective degeneration' did not appear to be correlated with the concentration of the
odorant. The results suggest a topological representation of different odors in the olfactory bulb.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
