Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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Reaction mass of trisodium bis[5-amino-2-(hydroxy-κO)-3-{[1-(hydroxy-κO)-2-naphthyl]diazenyl-κN1}benzenesulfonato(3-)]chromate(3-), trisodium bis[2-(hydroxy-κO)-3-{[1-(hydroxy-κO)-2-naphthyl]diazenyl-κN1}-5-nitrobenzenesulfonato(3-)]chromate(3-) and heptasodium bis[4-(hydroxy-κO)-3-{[2-(hydroxy-κO)-5-nitro-3-sulfophenyl]diazenyl-κN2}-6-(4-sulfoanilino)naphthalene-2-sulfonato(5-)]chromate(7-)
EC number: 944-619-2 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- other: data obtained after Article 25(3) request
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Acid Black 173 - Similar Substance 01
- IUPAC Name:
- Acid Black 173 - Similar Substance 01
- Test material form:
- not specified
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- HC:NZW
Test system
- Amount / concentration applied:
- 70 mg
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal: 1, 2, 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal: 1, 2, 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 1, 2, 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 1
- Irritation parameter:
- iris score
- Basis:
- animal: 1, 2, 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes fully reversible within 1 days
- Other effects:
- None
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- Non eye irritant
- Executive summary:
Method
The substance has been tested for its skin irritation potential according to the OECD guideline 405.
Results
Non eye irritant
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