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Diss Factsheets
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EC number: 946-154-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- only one sex tested, limitations in study reporting
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Type:
- Constituent
- Type:
- Constituent
- Type:
- Constituent
- Type:
- Constituent
- Test material form:
- solid
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Test animals:
- Strain: Hoe WISKf(SPF71)
- Source: Hoechst AG Kastengrund - SPF breed
- Weight at study initiation: 90-112 g (female); (mean = 100 g; n = 60)
- Age at study initiation: no data
- Fasting period before study: 16 hours before and 2 hours after application
- Diet: Altromin 1324 (Altromin GmbH, Lage/Lippe), ad libitum
- Water: Tap water ad libitum
- Acclimatization period: no data
Environmental conditions:
- Housing: in groups, in plastic cages, softwood pellets
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Concentration in vehicle: 25 % (w/v)
- Doses:
- 6300, 8000, 9000, 10000, 12500 and 15000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical observations after application / weighing once weekly
- Necropsy of survivors performed: yes - Statistics:
- Probit analysis (method by Linder and Weber); Confidence limits according to Cavalli-Sforza
Results and discussion
- Preliminary study:
- Preliminary experiments did not show differences related to gender. Therefore only females used for main study.
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 10 490 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 9 833 - <= 11 191
- Remarks on result:
- other: corresponding to 2623 mg a.i./kg bw
- Remarks:
- with a concentration correction of 25%
- Mortality:
- Mortality rate:
- 6300 mg/kg bw: 0 / 10
- 8000 mg/kg bw: 0 / 10
- 9000 mg/kg bw: 0 / 10
- 10000 mg/kg bw: 5 / 10
- 12500 mg/kg bw: 9 / 10
- 15000 mg/kg bw: 10 / 10 - Clinical signs:
- Mortally poisened animals died within 1-2 days after application. Following symptoms were observed: disturbance of equilibrium, spasm. The test substance was vomitted.
- Body weight:
- Normal body weight gain was observed in all surviving animals.
- Gross pathology:
- Dissection of rats killed at the end of the observation period revealed no macroscopic findings. Necropsy of the deceased animals revealed following macroscopic findings: stomach and oesophagus were filled with white foam.
Applicant's summary and conclusion
- Conclusions:
- Under the study conditions, the female rat LD50 of the test substance was determined to be 10490 mg/kg bw, corresponding to 2623 mg a.i./kg bw (oral: gavage).
- Executive summary:
A study was conducted to determine the acute oral toxicity of the test substance according to OECD guideline 401 (standart acute method). The test substance was administered by gavage to ten female Wistar rats at concentrations of 0, 6300, 8000, 9000, 10000, 12500 and 15000 mg/kg bw (25%, in water). The duration of the observation period following administration was 14 days. Clinical observations were recorded after application and weighing once weekly. Macroscopic examination was performed on all animals. Mortality occurred in the groups 10000, 12500 and 15000 mg/kg bw (5, 9 and 10/10, respectively). Mortally poisened animals died within 1-2 days after application. Disturbance of equilibrium and spasm were observed. The test substance was vomitted. Normal body weight gain was recorded in all surviving animals. Dissection of rats killed at the end of the observation period revealed no macroscopic findings. Necropsy of the deceased animals revealed the following macroscopic findings: stomach and oesophagus were filled with white foam. Under the study conditions, the female rat LD50 of the test substance was determined to be 10490 mg/kg bw, corresponding to 2623 mg a.i./kg bw (1974).
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