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EC number: 271-636-6 | CAS number: 68603-09-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48 hour LL50 >100 mg/L loading rate WAF, Daphnia magna, OECD 202, Goodband 2012b
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Key Study
The potential for a structurally analogous substance to cause acute toxic effects to aquatic invertebrates was determined in a GLP compliant study (Goodband, 2012b) performed according to the standardised guidelines OECD 202 and Method C.2 of the Commission Regulation (EC) No. 440/2008. The study was reported in sufficient detail to provide an accurate assessment of the results and study quality, and to accurately represent the toxicity of the material.
Following a preliminary range-finding test, twenty daphnids were exposed to Water Accommodated Fractions (WAFs) of the test material, over a range of nominal loading rates of 1.0, 1.8, 3.2, 5.6, 8.0, 18, 32, 56 and 100 mg/l for a period of 48 hours at a temperature of approximately 21 °C under static test conditions.
The 48-Hour EL50 based on nominal loading rates was greater than 100 mg/l loading rate WAF. The No Observed Effect Loading rate was 100 mg/l loading rate WAF.
The study was performed to a good standard and was assigned a reliability score of 2 using the principles for assessing data quality as set out in Klimisch (1997) as a result of the data being used in a read across capacity. Read across is justified on the basis of similar chemical structures and analogous results from a batch of physico-chemical tests, including water solubility.
Supporting Information
The acute toxicity to aquatic invertebrates of a second structural analogue was investigated in Daphnia magna in accordance with the standardised guideline OECD 202. The Daphnia were exposed to a Water Accommodated Fraction (WAF) of test material which was prepared according to a modified ASTM method. Following a preliminary study, groups of 5 daphnia were exposed to test material at the following concentrations: 0, 625, 1250, 2500, 5000 and 10000 mg/L (as WAF). Sodium chloride was used as the reference substance. In the definitive study, no mortalities were observed up to 2500 mg/L. Two daphnia dosed at 5000 mg/L WAF were found dead/immobilised after 24 hours in replicate A. All daphnia dosed at 10000 mg/L WAF were found dead/immobilised after 48 hours in all replicates. Under the conditions of the study, the LL50 of the test material was determined to be 7070 mg/L with 95 % confidence limits of 5000 - 10000 mg/L.
The non-GLP study was performed in line with an accepted standardised guideline with a sufficient level of reporting to assess the quality of the relevant results. The study was assigned a reliability score of 2 and considered suitable for assessment as an accurate reflection of the test material. However, it was deemed more appropriate to select the first study as the key data to be used as ut is considered more reliable.
The available data are considered to be complete and the result determined, 48 h LL50 value of >100 mg/L loading rate WAF, was taken forward for risk assessment.
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