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EC number: 238-947-9 | CAS number: 14874-82-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study apparently performed according to the method described in Federal Register 1973, Vol. 38, No. 187, Section 1500:41, which has some significant deviations from current OECD guidelines. Limited reporting, notably of test material (e.g. purity).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Skin irritation patch test, as described in Federal Register 1973, Vol. 38, No. 187, Section 1500:41.
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dicarbonyl(pentane-2,4-dionato-O,O')rhodium
- EC Number:
- 238-947-9
- EC Name:
- Dicarbonyl(pentane-2,4-dionato-O,O')rhodium
- Cas Number:
- 14874-82-9
- Molecular formula:
- C7H7O4Rh
- IUPAC Name:
- Dicarbonyl(pentane-2,4-dionato-O,O')rhodium
- Details on test material:
- - Name of test material (as cited in study report): rhodium dicarbonyl acetylacetonate
- Lot/batch No.: Sample CB.23
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: “recognised breeders”
- Age at study initiation: 16-18 weeks
- Weight at study initiation: 2.2-2.4 kg
- Housing: unspecified numbers per cage
- Diet: ad libitum commercial rabbit diet supplied by Rank Hovis MacDougal
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): “natural lighting conditions”
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: Backs of the rabbits were shaved (not “closely clipped” as recommended by the OECD guidelines). One site of each rabbit was abraded immediately before application of the test material, the other site remained intact.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 24 hrs
- Observation period:
- 48 hrs after removal of the patch
- Number of animals:
- six
- Details on study design:
- TEST SITE
- Area of exposure: Each site 2.5 cm2 (one intact, one abraded)
- % coverage: at least 10%
- Type of wrap if used: Gauze pad was secured by “Sleek” adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): None
SCORING SYSTEM: Erythema (and eschar) formation and oedema formation were assessed on the intact and abraded skin of six rabbits at 24 and 72 hr after initial application of the test compound (i.e. as soon as the dressing was removed and again 48 hrs later). The primary irritation index was calculated by adding the four values for erythema (and eschar) formation to the four for oedema formation, and dividing the total by four. According to the study report, Draize (1959) considers that “compounds producing combined averages (primary irritation indices) of 2 or less are only mildly irritating; whereas those with indices of 2 to 5 are moderate irritants, and those with scores above 6 are considered severe irritants”.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hrs after initial application
- Score:
- 0.7
- Max. score:
- 8
- Reversibility:
- other: Reversibility not assessed, as observation period only 48 hrs (not up to 14 days as recommended in the OECD guidelines). However, on the majority of occasions where irritation (score of 1 or 2) was noted after dressing removal, the severity of the irritat
- Remarks on result:
- other: Average score for abraded and intact skin
- Irritant / corrosive response data:
- On the intact skin, slight erythema was seen in two (out of 6) rabbits assessed after dressing removal, which was still observed on one of these animals assessed 48 hours later. No oedema was reported on the intact skin of any treated animals assessed at either time point (0 or 48 hours after dressing removal).
- Other effects:
- No further effects were reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an in vivo skin irritation study, rhodium dicarbonyl acetylacetonate (0.5 mL) produced a primary irritation index of 0.7 following 24-hr occlusive application to the shaved abraded and intact skin of six rabbits. This study was not performed to current OECD guidelines.
- Executive summary:
Rhodium dicarbonyl acetylacetonate (0.5 ml) was applied (occluded) to the shaved abraded and intact skin of six albino rabbits. After 24 hrs, the dressings were removed and the sites were quantitatively assessed for erythema (and eschar) formation and oedema formation. Similar assessments were made 48 hrs later. The sum of these values was combined and divided by four to give a primary irritation score of 0.7 (out of a possible 8).On the intact skin, slight erythema (but no oedema) was seen in two rabbits assessed after dressing removal, which was still observed on one of these animals assessed 48 hours later. Overall, rhodium dicarbonyl acetylacetonate was mildly irritating in this test system as there was a tendency for reversibility of effects over time.
This study suffered from a number of significant deviations from the recommendations given in the current OECD guidelines. These included use of abraded skin, a longer exposure period, failure to wash off any residual test material after removal of the dressing, an insufficient observation period to assess reversibility of effects, and the skin was only examined on two occasions (at 0 and 48 hrs), rather than at 1, 24, 48 and 72 hrs after patch removal. However, certain of these deviations would have likely increased the possibility of an irritant reaction .
Mean erythema and oedema scores were below 2.3 for all six animals. Accordingly, rhodium dicarbonyl acetylacetonate does not require classification for skin irritation according to EU CLP criteria (EC 1272/2008).
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