Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-100-8 | CAS number: 13161-30-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from authoritative database
Data source
Reference
- Reference Type:
- other: Authoritative database
- Title:
- HSDB for the CAS: 108-99-6
- Author:
- U.S National Library of Medicine
- Year:
- 2 015
- Bibliographic source:
- Hazardous Substances Data Bank (HSDB), U.S National Library of Medicine, last updated 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal irritation potential of 3-methylpyridine in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-methylpyridine
- EC Number:
- 203-636-9
- EC Name:
- 3-methylpyridine
- Cas Number:
- 108-99-6
- Molecular formula:
- C6H7N
- IUPAC Name:
- 3-methylpyridine
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 3-methylpyridine
- Molecular formula: C6H7N
- Molecular weight: 93.1283 g/mol
- Substance type: organic
- Physical state: liquid
- Smiles: c1(cccnc1)C
- InChI: 1S/C6H7N/c1-6-3-2-4-7-5-6/h2-5H,1H3
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 3-methylpyridine
- Molecular formula: C6H7N
- Molecular weight: 93.1283 g/mol
- Substance type: organic
- Physical state: liquid
- Smiles: c1(cccnc1)C
- InChI: 1S/C6H7N/c1-6-3-2-4-7-5-6/h2-5H,1H3
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Details on test animals or test system and environmental conditions:
- sex: male
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- no data available
- Duration of treatment / exposure:
- single exposure
- Observation period:
- till 7 or 14 days
- Number of animals:
- no data available
- Details on study design:
- SCORING SYSTEM: The skin irritation potential was characterized by cutaneous primary irritation index (PII)
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- other:
- Basis:
- mean
- Time point:
- other: 7 or 14 days
- Score:
- 6.8
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- Severely irritating to rabbit skin
- Other effects:
- Histological examination of the skin showed necrosis, ulceration and regeneration of tissues.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The Primary Irritation index (PII) for 3-methylpyridine was 6.8. Histological examination of the skin showed necrosis, ulceration and regeneration of tissues.
Based on these observations, 3-methylpyridine can be considered to be severely irritating to rabbit skin. - Executive summary:
The dermal irritation potential of 3-methylpyridine was assessed in rabbits. Undiluted 3-methylpyridine was applied to the skin of male New Zealand albino rabbits and observed for signs of irritation till 7 or 14 days.Following 7 or 14 days rabbits were killed and histological examinations were performed on the test site.The skin irritation potential was characterized by cutaneous primary irritation index (PII).
The Primary Irritation index (PII) for 3-methylpyridine was 6.8. Histological examination of the skin showed necrosis, ulceration and regeneration of tissues.
Based on these observations, 3-methylpyridine can be considered to be severely irritating to rabbit skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
