1-propoxypropan-2-ol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1985

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: non-GLP study equivalent to OECD guideline 403

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1985

Report date:

1985

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1-propoxypropan-2-ol

EC Number:

216-372-4

EC Name:

1-propoxypropan-2-ol

Cas Number:

1569-01-3

Molecular formula:

C6H14O2

IUPAC Name:

1-propoxypropan-2-ol

Details on test material:

propylene glycol n-propyl ether (CAS 1569-01-3)

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River Breeding Laboratory, Kinsgton, NY
- Age at study initiation: 8 weeks
- Fasting period before study: n.a.
- Housing: individual housing in stainless steel wire mesh cages
- Diet (e.g. ad libitum): standard Purina diet ad libitum (except during exposure)
- Water (e.g. ad libitum): ad libitum (except during exposure)
- Acclimation period: minimum 2 weeks

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C
- Humidity (%): 50%
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12 hours


IN-LIFE DATES: From: To:

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: glass and stainless steel Rochester-type chambers under dynamic airflow conditions
- Exposure chamber volume: 112 liter
- Source and rate of air: 30 liters/min
- Method of conditioning air: test material was pumped into a counter-current, multi-plated distillation colum where it was vaporized and mixed with compressed air
- Temperature, humidity in air chamber: 24-26°C, 31-32% humidity,


TEST ATMOSPHERE
- Samples taken from breathing zone: no (nominal chamber concentration was calculated based on the amount of test material used and the total amount of air that passed through the chamber during the xposure period)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

4 h

Concentrations:

0, 1725 ppm (highest concentration attainable at room temperature 25°C)

No. of animals per sex per dose:

6 male rats

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation-during exposure and at least once per day during observation period; weighing-on the first day and twice per week during observation period

Statistics:

Means and standard deviations of animal body weights were calculated for descriptive purposes.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC0

Effect level:

> 1 725 ppm

Exp. duration:

4 h

Remarks on result:

other: highest attainable concentration at room temperature

Mortality:

no mortality

Clinical signs:

other: none

Body weight:

Body weights of animals exposed to the test material were comparable to control values throughout the two week observation period and all animals appeared to be within normal health limits during the post-exposure period.

Other findings:

- Other observations: During exposure, the rats being exposed to the test material appeared to be slightly lethargic; rats in the control chamber appeared to be normal.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Based on the results of this study, PnP should not pose any significant acute inhalation hazards in humans; although a slight sedative effect may occur with prolonged exposure to near-staurated atmospheres.

Executive summary:

Six male rats were exposed for four hours to vapors of propylene glycol propyl ether (PnP) at a nominal concentration of 1725 ppm. This was the highest concentration attainable at room temperature (25°C). Simultaneously, 6 male rats (serving as controls) were housed in a chamber supplied with clean, filtered air. Animals exposed to the test material appeared to be slightly lethargic during exposure. Mean body weights of exposed animals were comparable to to control values throughout the two week observation period and each animal appeared to be within normal health limits. No mortality was encountered in association with exposure to this test material. Based on the results of this study, PnP should not pose any significant acute inhalation hazards in humans. A slight sedative effect may occur however, with prolonged exposure to saturadted atmospheres.