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Diss Factsheets
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EC number: 944-574-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 March 1974 to 18 April 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Five groups of 5 male fasted animals was given a single oral dose of test material as a solution in Corn Oil at dose levels of 2.0 mL/kg, 4.0 mL/kg, 8 mL/kg, 16.0 mL/kg and 32.0 mL/kg The animals were observed for fourteen days after the day of dosing.
- GLP compliance:
- no
- Remarks:
- Prior to GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sherman-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Test Animals
- Weight at study initiation - 200 to 250g
- Fasting period before study - 24 hours prior to dosing
- Diet - With the exception of an 24 hour fast prior to dosing, free access to food and water was allowed through the study
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25% w/v suspension
MAXIMUM DOSE VOLUME APPLIED: 32ml/kg
: - Doses:
- 2.0 ml/kg
4.0 ml/kg
8.0 ml/kg
16.0 ml/kg
32.0 ml/kg - No. of animals per sex per dose:
- 5 males
- Control animals:
- no
- Details on study design:
- The animals were observed for signs of toxicity and mortality daily for 14 days.
- Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 32 mL/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occured during the course of the study
- Clinical signs:
- No data
- Body weight:
- No data
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Section 1500.3 - Hazardous Substances and Articles, Administraton and Enforcement Regulations, Federal Register, Vol. 38 No 187 P.27014, 27 September 1973, Section (c) (2) (1)
- Conclusions:
- The Acute Oral LD50 in the male Sherman-Wistar rat was found to be greater than 32 mL/kg (equivalent to 8 g/kg)
- Executive summary:
Guideline
A study was performed to assess the acute oral toxicity of the test material in the Sherman-Wistar strain rat.
Method
Five groups of 5 male fasted animals was given a single oral dose of test material as a solution in Corn Oil at dose levels of 2.0 mL/kg, 4.0 mL/kg, 8.0 mL/kg, 16.0 mL/kg and 32.0 mL/kg The animals were observed for fourteen days after the day of dosing.
Results
There were no deaths. The acute oral median lethal dose (LD50) of the test material in the Sherman-Wistar strain rat was found to be greater than 32 mL/kg bodyweight.
Conclusion
The Acute Oral LD50 in the male Sherman-Wistar rat was found to be greater than 32 mL/kg (equivalent to 8 g/kg).
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