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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data from secondary source

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Evaluation of health hazards by exposure to Chlorinated paraffins and proposal of a health-based quality criterion for ambient air
Author:
The Danish Environmental Protection Agency
Year:
2013
Bibliographic source:
The Danish Environmental Protection Agency, 2013
Reference Type:
secondary source
Title:
Risk assessment of alkanes, c14-17, chloro (medium-chained chlorinated paraffins) CAS no. 85535-85-9
Author:
European Chemicals Agency (ECHA)
Year:
2008
Bibliographic source:
Risk assessment of alkanes, c14-17, chloro (medium-chained chlorinated paraffins),2008

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: As mention below
Principles of method if other than guideline:
Acute oral toxicity study of Alkanes C14-17, chloro was performed in Rat
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): Alkanes C14-17, chloro
- Molecular formula : No data available
- Molecular weight : No data available
- Substance type: organic
- Physical state: liquid
- Purity: No data available
- Impurities (identity and concentrations): No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report): Alkanes C14-17, chloro
- Molecular formula : No data available
- Molecular weight : No data available
- Substance type: organic
- Physical state: liquid
- Purity: No data available
- Impurities (identity and concentrations): No data available

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
15000mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 15 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed
Clinical signs:
signs of toxicity included urinary incontinence or “oily/moist pelt around the anal-genital region” were observed
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be >15000mg/kg body weight. When rats were treated with Alkanes C14-17, chloro (85535-85-9) orally.
Executive summary:

Acute oral toxicity study was done in rat using Alkanes C14-17, chloro(85535-85-9).No mortality observed in treated rat at dose 15000mg/kg .Clinical signs like urinary incontinence or “oily/moist pelt around the anal-genital region ”were observed in treated rats. HenceLD50 was considered to be>15000mg/kgbody weight. When rats were treated with Alkanes C14-17, chloro (85535-85-9) orally.