Registration Dossier
Registration Dossier
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EC number: 203-462-3 | CAS number: 107-10-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- 49 CFR 173.240 Method
- GLP compliance:
- no
Test material
- Reference substance name:
- Propylamine
- EC Number:
- 203-462-3
- EC Name:
- Propylamine
- Cas Number:
- 107-10-8
- Molecular formula:
- C3H9N
- IUPAC Name:
- propan-1-amine
- Details on test material:
- Clear colorless liquid
No other data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- No data
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 3 days
- Number of animals:
- 6
- Details on study design:
- No data
Results and discussion
In vivo
- Irritant / corrosive response data:
- When exposures were terminated, all treated sites were thick and erythematous; surface dermatolysis was present in 3 of the animals.
Subsequently, these sites became dry, hard and concave,. This reaction is characteristic of dry necrosis.
Any other information on results incl. tables
When exposures were terminated, all treated sites were thick and erythematous; surface dermatolysis was present in three of the animals. Subsequently these sites became dry, hard, and concave. This reaction is characteristic of dry necrosis.
Under these experimental conditions, mono-n-propylamine is considered as corrosive to the skin.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
