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EC number: 701-138-0 | CAS number: 242482-67-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No acute toxicity on freshwater invertebrates observed up to the tested limit concentration of 400 mg/L (analytically verified).
Key value for chemical safety assessment
Additional information
Acute toxicity on freshwater invertebrates was tested using Daphnia magna in a reliable (reliability category 1) study performed with the submission substance 6-(isononanoylamino)hexanoic acid, compound with 2,2’,2’’-nitrilotriethanol compliant to GLP and according to relevant test guidelines. Test item concentrations 400, 200, 100, 50, and 25 mg were analytically confirmed to be on average 102 % of nominal during the 48 hour test period. No immobilisation of the test animals was observed in the control and for the test item up to and including the highest test item concentration of 400 mg/L.
As regards marine invertebrates, two studies with the submission substance 6-(isononanoylamino)hexanoic acid, compound with 2,2’,2’’-nitrilotriethanol performed in close temporal succession on the marine invertebrate Acartia tonsa (herbivore copepod) are available. The studies were performed according to ISO 14669:1999(E) draft guideline but are insufficiently documented (e.g. no information on number of test organism used / affected per concentration, no data on statistical evaluation, no data on test item purity) and equivocal especially in regard to derived (no)effect concentrations. Thus both studies are not reliable (reliability category 3). Concentrations between 2 mg/L and 20 mg/L respectively 35.6 mg/L (second study) were tested. At all concentrations some immobilization was observed (including the control for the second study with 5% and the control in the range finding test of the first study with 90% immobilization), but a dose-response relationship was seen at least for the 48 h-values in both final studies. Reported EC50-values are 5.9 (first study) and 10.5 mg/L (second study). Thus marine invertebrates may be more susceptible to 6-(isononanoylamino)hexanoic acid, compound with 2,2’,2’’-nitrilotriethanol than freshwater organisms, but no firm conclusions can be drawn from these two unreliable studies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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